Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) ykfI-yfjZ/CbtA-CbeA
Location 4395673..4396364 Replicon chromosome
Accession NZ_OU342706
Organism Klebsiella pneumoniae strain Kp1 isolate Kp1

Toxin (Protein)


Gene name ykfI Uniprot ID A0A483YFJ1
Locus tag KXF33_RS21610 Protein ID WP_025987721.1
Coordinates 4395673..4396014 (-) Length 114 a.a.

Antitoxin (Protein)


Gene name yfjZ Uniprot ID A0A2A5MHA6
Locus tag KXF33_RS21615 Protein ID WP_019725272.1
Coordinates 4396038..4396364 (-) Length 109 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KXF33_RS21595 (KP1VIM_04289) 4392646..4393881 - 1236 WP_124044824.1 hypothetical protein -
KXF33_RS21600 (KP1VIM_04290) 4394327..4394698 - 372 WP_223369725.1 hypothetical protein -
KXF33_RS21605 (KP1VIM_04291) 4394725..4395558 - 834 WP_025987720.1 DUF4942 domain-containing protein -
KXF33_RS21610 (KP1VIM_04292) 4395673..4396014 - 342 WP_025987721.1 TA system toxin CbtA family protein Toxin
KXF33_RS21615 (KP1VIM_04293) 4396038..4396364 - 327 WP_019725272.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
KXF33_RS21620 (KP1VIM_04294) 4396378..4396854 - 477 WP_019725273.1 DNA repair protein RadC -
KXF33_RS21625 (KP1VIM_04295) 4396864..4397310 - 447 WP_025987722.1 antirestriction protein -
KXF33_RS21630 (KP1VIM_04296) 4397522..4398211 - 690 WP_009309812.1 hypothetical protein -
KXF33_RS21635 (KP1VIM_04297) 4398776..4399666 - 891 WP_019725276.1 YfjP family GTPase -
KXF33_RS21640 (KP1VIM_04298) 4399749..4400837 - 1089 WP_019725277.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 4378605..4418774 40169


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-107)

Antitoxin

Antitoxin CbeA

(8-107)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12867.90 Da        Isoelectric Point: 8.5195

>T294718 WP_025987721.1 NZ_OU342706:c4396014-4395673 [Klebsiella pneumoniae]
MKTLPATIQRAAKPCPSPVTVWQMLLTRLLEQHYGLTLNDTPFSDETVIQEHINAGITLVDAVNFLVEKYELVRIDRRGF
NCQEQSPYLGAVDILRARQATGLLRQRHLPSIR

Download         Length: 342 bp

Antitoxin


Download         Length: 109 a.a.        Molecular weight: 12276.01 Da        Isoelectric Point: 6.9560

>AT294718 WP_019725272.1 NZ_OU342706:c4396364-4396038 [Klebsiella pneumoniae]
MPLTDAIQWGLKRSFTPNFGARLVQEGNRLHYLADRANITGKFGDAECLKLEEAFPHFIRQMELMLSTGELNPRHAHSVT
LYHNAFTCEADTLGSCGYVYIVIYPTQR

Download         Length: 327 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A483YFJ1

Antitoxin

Source ID Structure
AlphaFold DB A0A2A5MHA6

References