Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) kacAT/DUF1778(antitoxin)
Location 4351774..4352584 Replicon chromosome
Accession NZ_OU342706
Organism Klebsiella pneumoniae strain Kp1 isolate Kp1

Toxin (Protein)


Gene name KacT Uniprot ID A0A0H3GMP0
Locus tag KXF33_RS21405 Protein ID WP_002887280.1
Coordinates 4351774..4352307 (-) Length 178 a.a.

Antitoxin (Protein)


Gene name KacA Uniprot ID J2E9Q7
Locus tag KXF33_RS21410 Protein ID WP_002887278.1
Coordinates 4352318..4352584 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KXF33_RS21400 (KP1VIM_04246) 4350605..4351726 + 1122 WP_009309849.1 cupin domain-containing protein -
KXF33_RS21405 (KP1VIM_04247) 4351774..4352307 - 534 WP_002887280.1 type II toxin-antitoxin system toxin KacT Toxin
KXF33_RS21410 (KP1VIM_04248) 4352318..4352584 - 267 WP_002887278.1 type II toxin-antitoxin system antitoxin KacA Antitoxin
KXF33_RS21415 (KP1VIM_04249) 4352687..4354120 - 1434 WP_019724905.1 Cu(+)/Ag(+) sensor histidine kinase -
KXF33_RS21420 (KP1VIM_04250) 4354110..4354793 - 684 WP_004214143.1 copper response regulator transcription factor CusR -
KXF33_RS21425 (KP1VIM_04251) 4354965..4356347 + 1383 WP_019724904.1 efflux transporter outer membrane subunit -
KXF33_RS21430 (KP1VIM_04252) 4356365..4356709 + 345 WP_025987660.1 cation efflux system protein CusF -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(91-151)

Antitoxin

Vibrio phage ICP1, Orf50

(2-86)


Sequences

Toxin        


Download         Length: 178 a.a.        Molecular weight: 19838.70 Da        Isoelectric Point: 5.2614

>T294717 WP_002887280.1 NZ_OU342706:c4352307-4351774 [Klebsiella pneumoniae]
MEQQLTIEMIADAFSYDITGFDCGEEALNTFLKEHLKRQHDGQILRGYALVSGDTVPRLLGYYTLSGSCFERGMLPSKTQ
QKKIPYQNAPSVTLGRLAIDKSVQGQGWGEMLVAHVMRVVWGASKAVGIYGLFVEALNEKAKAFYLRLGFIQLVDENSNL
LFYPTKSIEQLFTDDES

Download         Length: 534 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9996.46 Da        Isoelectric Point: 10.1757

>AT294717 WP_002887278.1 NZ_OU342706:c4352584-4352318 [Klebsiella pneumoniae]
MPALKKQRIDLRLTDDDKSIIEEAAAISNQTITQFVVASASERAAEVIEQHRRMVLNEQSWSLVMEAITQPPAPNDRLKR
AAKRLQTR

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 5ZGN
PDB 5XUN

Antitoxin

Source ID Structure
PDB 5ZGN
AlphaFold DB A0A0H3GLZ1

References