Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2345954..2347542 Replicon chromosome
Accession NZ_OU342706
Organism Klebsiella pneumoniae strain Kp1 isolate Kp1

Toxin (Protein)


Gene name hipA Uniprot ID W8UI36
Locus tag KXF33_RS11565 Protein ID WP_002904792.1
Coordinates 2345954..2347276 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A0H3GXD8
Locus tag KXF33_RS11570 Protein ID WP_002904790.1
Coordinates 2347276..2347542 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KXF33_RS11550 (KP1VIM_02294) 2341010..2343511 + 2502 WP_064145444.1 fimbria/pilus outer membrane usher protein -
KXF33_RS11555 (KP1VIM_02295) 2343499..2344503 + 1005 WP_064145446.1 fimbrial protein -
KXF33_RS11560 (KP1VIM_02296) 2344645..2345937 + 1293 WP_064145447.1 glycoside hydrolase family 10 protein -
KXF33_RS11565 (KP1VIM_02297) 2345954..2347276 - 1323 WP_002904792.1 type II toxin-antitoxin system HipA family toxin Toxin
KXF33_RS11570 (KP1VIM_02298) 2347276..2347542 - 267 WP_002904790.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
KXF33_RS11575 (KP1VIM_02299) 2347930..2348256 - 327 WP_002904788.1 hydroxyisourate hydrolase -
KXF33_RS11580 (KP1VIM_02300) 2348253..2348753 - 501 WP_064145448.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
KXF33_RS11585 (KP1VIM_02301) 2348731..2350110 - 1380 WP_064145449.1 nucleobase:cation symporter-2 family protein -
KXF33_RS11590 (KP1VIM_02302) 2350456..2351610 + 1155 WP_023282572.1 FAD-dependent urate hydroxylase HpxO -
KXF33_RS11595 (KP1VIM_02303) 2351591..2352514 - 924 WP_064145450.1 LysR family hpxDE operon transcriptional regulator HpxR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(149-402)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49171.46 Da        Isoelectric Point: 7.5357

>T294715 WP_002904792.1 NZ_OU342706:c2347276-2345954 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9906.27 Da        Isoelectric Point: 8.5912

>AT294715 WP_002904790.1 NZ_OU342706:c2347542-2347276 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E1CEC8

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GXD8

References