29471

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 1962018..1962478 Replicon chromosome
Accession NC_021251
Organism Mycobacterium tuberculosis CCDC5079

Toxin (Protein)


Gene name vapC Uniprot ID G0TKL9
Locus tag CFBS_RS09165 Protein ID WP_003898996.1
Coordinates 1962230..1962478 (+) Length 83 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ30
Locus tag CFBS_RS09160 Protein ID WP_003408528.1
Coordinates 1962018..1962230 (+) Length 71 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CFBS_RS09145 1958496..1959683 - 1188 WP_014585215.1 nitrate transporter NarK -
CFBS_RS09150 1959970..1960254 + 285 WP_003408522.1 DUF1876 domain-containing protein -
CFBS_RS09155 1960268..1961950 - 1683 WP_003901239.1 SulP family inorganic anion transporter -
CFBS_RS09160 1962018..1962230 + 213 WP_003408528.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
CFBS_RS09165 1962230..1962478 + 249 WP_003898996.1 type II toxin-antitoxin system VapC family toxin Toxin
CFBS_RS09170 1962486..1963223 + 738 WP_003898997.1 hypothetical protein -
CFBS_RS09175 1963317..1965017 + 1701 WP_003898998.1 serine/threonine protein kinase PknE -
CFBS_RS09180 1965302..1965703 - 402 WP_003408538.1 hypothetical protein -
CFBS_RS09185 1965693..1966304 - 612 WP_003898999.1 isopentenyl-diphosphate Delta-isomerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Antitoxin VapB-like

(2-69)


Sequences

Toxin        


Download         Length: 83 a.a.        Molecular weight: 8884.14 Da        Isoelectric Point: 4.1074

>T29471 WP_003898996.1 NC_021251:1962230-1962478 [Mycobacterium tuberculosis CCDC5079]
MVIDTSALVAMLNDEPEAQRFEIAVAADHVWLMSTASYPEMATVIETRFGEPGGREPKVSGQPLLYKGDDFACIDIRAVL
AG

Download         Length: 249 bp

>T29471 NC_021251:1962230-1962478 [Mycobacterium tuberculosis CCDC5079]
ATGGTGATCGATACCTCTGCGCTGGTCGCGATGCTCAACGATGAACCCGAGGCGCAACGGTTCGAGATAGCCGTGGCAGC
AGACCACGTTTGGCTGATGTCGACGGCGTCATATCCGGAGATGGCGACCGTGATCGAAACACGCTTCGGGGAACCGGGGG
GACGTGAACCCAAGGTCAGCGGCCAGCCTCTCCTCTATAAGGGTGACGATTTCGCATGTATCGATATTCGCGCGGTTCTC
GCCGGCTGA

Antitoxin


Download         Length: 71 a.a.        Molecular weight: 7607.80 Da        Isoelectric Point: 9.3146

>AT29471 WP_003408528.1 NC_021251:1962018-1962230 [Mycobacterium tuberculosis CCDC5079]
MELAARMGETLTQAVVVAVREQLARRTGRTRSISLREELAAIGRRCAALPVLDTRAADTILGYDERGLPA

Download         Length: 213 bp

>AT29471 NC_021251:1962018-1962230 [Mycobacterium tuberculosis CCDC5079]
ATGGAATTGGCGGCTCGAATGGGCGAGACTTTGACACAAGCGGTCGTAGTTGCAGTGCGGGAGCAACTGGCCCGCCGGAC
CGGGCGCACCAGATCCATTTCGCTACGCGAGGAGTTGGCCGCCATTGGCCGGCGCTGCGCGGCCTTACCGGTGCTCGACA
CCCGAGCCGCGGACACGATTCTCGGCTACGACGAGCGCGGGTTGCCCGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TKL9

Antitoxin

Source ID Structure
AlphaFold DB A0A829CFE8

References