Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | Xre-MNT/HTH_26(antitoxin) |
Location | 18665..19773 | Replicon | plasmid pl2 |
Accession | NZ_OU016039 | ||
Organism | Enterococcus faecium isolate USZ_VRE53_P46 |
Toxin (Protein)
Gene name | MNTss | Uniprot ID | R3JIN1 |
Locus tag | KKQ98_RS15815 | Protein ID | WP_000233000.1 |
Coordinates | 18665..19534 (-) | Length | 290 a.a. |
Antitoxin (Protein)
Gene name | Xress | Uniprot ID | - |
Locus tag | KKQ98_RS15820 | Protein ID | WP_000205227.1 |
Coordinates | 19549..19773 (-) | Length | 75 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
KKQ98_RS15780 | 14143..14655 | - | 513 | WP_000774078.1 | hypothetical protein | - |
KKQ98_RS15785 | 14662..15180 | - | 519 | WP_000357244.1 | YfbU family protein | - |
KKQ98_RS15790 | 15342..15554 | - | 213 | WP_002349227.1 | hypothetical protein | - |
KKQ98_RS15795 | 15763..16443 | + | 681 | WP_001067799.1 | IS6-like element IS1216 family transposase | - |
KKQ98_RS15800 | 16532..17012 | - | 481 | Protein_20 | GNAT family N-acetyltransferase | - |
KKQ98_RS15805 | 17009..17917 | - | 909 | WP_001255866.1 | aminoglycoside nucleotidyltransferase ANT(6)-Ia | - |
KKQ98_RS15810 | 17950..18684 | - | 735 | WP_000662263.1 | class I SAM-dependent methyltransferase | - |
KKQ98_RS15815 | 18665..19534 | - | 870 | WP_000233000.1 | nucleotidyltransferase domain-containing protein | Toxin |
KKQ98_RS15820 | 19549..19773 | - | 225 | WP_000205227.1 | helix-turn-helix transcriptional regulator | Antitoxin |
KKQ98_RS15825 | 19916..20107 | - | 192 | Protein_25 | recombinase family protein | - |
KKQ98_RS15830 | 20162..20842 | - | 681 | WP_001067799.1 | IS6-like element IS1216 family transposase | - |
KKQ98_RS15835 | 20917..21057 | - | 141 | Protein_27 | IS6 family transposase | - |
KKQ98_RS15840 | 21620..22483 | - | 864 | WP_002332783.1 | zeta toxin family protein | - |
KKQ98_RS15845 | 22485..22757 | - | 273 | WP_002326825.1 | antitoxin | - |
KKQ98_RS15850 | 22775..22990 | - | 216 | WP_001835296.1 | peptide-binding protein | - |
KKQ98_RS15855 | 23082..23978 | - | 897 | WP_002326827.1 | ParA family protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Non-Mobilizable plasmid | ant(6)-Ia / erm(B) / cat(pC221) / VanHAX | - | 1..47525 | 47525 | |
- | inside | IScluster/Tn | ant(6)-Ia / erm(B) / cat(pC221) | - | 11377..32052 | 20675 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 290 a.a. Molecular weight: 32926.57 Da Isoelectric Point: 4.8781
>T294706 WP_000233000.1 NZ_OU016039:c19534-18665 [Enterococcus faecium]
MVGNVIQIVTEKLSSLPFIEGIVLGGSRARGTHTENSDIDIGIYYNSDSFDLTAINQIATELDDKNRNNLVVPPGAWGDW
INGGGWLFINGYHVDLILRDIKRVEQIIKDTEQGIVTANYQTGHPHGYISAMYRGELAISKILYAKNESLCELKKQAEIY
PTALKKSLMNFFIFEAEFSLMFVKANAGVEDKYYIAGHVFRIISCLNQVLFACNNAYCINEKKAIKLLETFEYKPEKYAE
RVNHIFEVLGLSLFECYDMTEKLYKEVNEIVSEINNFLNEESSDERKQI
MVGNVIQIVTEKLSSLPFIEGIVLGGSRARGTHTENSDIDIGIYYNSDSFDLTAINQIATELDDKNRNNLVVPPGAWGDW
INGGGWLFINGYHVDLILRDIKRVEQIIKDTEQGIVTANYQTGHPHGYISAMYRGELAISKILYAKNESLCELKKQAEIY
PTALKKSLMNFFIFEAEFSLMFVKANAGVEDKYYIAGHVFRIISCLNQVLFACNNAYCINEKKAIKLLETFEYKPEKYAE
RVNHIFEVLGLSLFECYDMTEKLYKEVNEIVSEINNFLNEESSDERKQI
Download Length: 870 bp
Antitoxin
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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