Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907(toxin)
Location 500048..500619 Replicon chromosome
Accession NZ_OU016036
Organism Enterococcus faecium isolate USZ_VRE53_P46

Toxin (Protein)


Gene name mazF Uniprot ID Q3Y2B8
Locus tag KKQ98_RS02385 Protein ID WP_002286801.1
Coordinates 500278..500619 (+) Length 114 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A828ZZN9
Locus tag KKQ98_RS02380 Protein ID WP_002323011.1
Coordinates 500048..500278 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KKQ98_RS02350 495181..496512 + 1332 WP_002286818.1 FAD-containing oxidoreductase -
KKQ98_RS02355 496534..497160 + 627 WP_002286816.1 cysteine hydrolase -
KKQ98_RS02360 497343..497924 + 582 WP_002286813.1 TetR/AcrR family transcriptional regulator -
KKQ98_RS16205 498656..499218 + 563 Protein_467 SOS response-associated peptidase family protein -
KKQ98_RS02375 499423..499761 - 339 WP_002286804.1 hypothetical protein -
KKQ98_RS02380 500048..500278 + 231 WP_002323011.1 hypothetical protein Antitoxin
KKQ98_RS02385 500278..500619 + 342 WP_002286801.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
KKQ98_RS02390 501682..502808 + 1127 WP_094850654.1 IS3 family transposase -
KKQ98_RS02395 503411..503605 + 195 WP_002297028.1 hypothetical protein -
KKQ98_RS02400 503796..504045 + 250 Protein_473 transposase -
KKQ98_RS02405 504289..505119 - 831 WP_002286789.1 manganese catalase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(10-113)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 13302.68 Da        Isoelectric Point: 9.9044

>T294703 WP_002286801.1 NZ_OU016036:500278-500619 [Enterococcus faecium]
VSEERIYIPKKGDIVWIDFDPSVGKEIQKRRPGLVVSRYEFNRKTMFSVICPITSTIKNLPTRYSLPEELDIKGQVIITQ
LKSLDFKERKLKKIENLPLQDMAKIDQIIQYMF

Download         Length: 342 bp

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8523.39 Da        Isoelectric Point: 3.9078

>AT294703 WP_002323011.1 NZ_OU016036:500048-500278 [Enterococcus faecium]
MLVTKSRLQGSSVVVTLPSDNGKKPSENQEYIVVYSDDGTITLVPKIEDPFSGGEEAEYYEKDEWEDLTPEGREIL

Download         Length: 231 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829FD66

Antitoxin

Source ID Structure
AlphaFold DB A0A828ZZN9

References