29470

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 1941194..1941807 Replicon chromosome
Accession NC_021251
Organism Mycobacterium tuberculosis CCDC5079

Toxin (Protein)


Gene name vapC Uniprot ID P9WFA2
Locus tag CFBS_RS09045 Protein ID WP_003408465.1
Coordinates 1941194..1941583 (-) Length 130 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ52
Locus tag CFBS_RS09050 Protein ID WP_003408469.1
Coordinates 1941580..1941807 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CFBS_RS09015 1936823..1937737 + 915 WP_003898985.1 3-hydroxyacyl-CoA dehydrogenase family protein -
CFBS_RS09020 1937740..1938570 + 831 WP_003408448.1 cyclase family protein -
CFBS_RS09025 1938570..1938920 + 351 WP_003898986.1 cupin domain-containing protein -
CFBS_RS09030 1938973..1939791 + 819 WP_003408456.1 3-keto-5-aminohexanoate cleavage protein -
CFBS_RS09035 1939805..1940584 + 780 WP_003408460.1 IclR family transcriptional regulator -
CFBS_RS09045 1941194..1941583 - 390 WP_003408465.1 PIN domain-containing protein Toxin
CFBS_RS09050 1941580..1941807 - 228 WP_003408469.1 antitoxin Antitoxin
CFBS_RS09055 1942025..1943509 + 1485 WP_003408473.1 carboxylase -
CFBS_RS09060 1943506..1944753 + 1248 WP_003408476.1 serine hydrolase -
CFBS_RS09065 1944796..1945215 - 420 WP_003408483.1 hypothetical protein -
CFBS_RS09070 1945205..1945915 - 711 WP_003408486.1 winged helix-turn-helix transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-116)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 13817.98 Da        Isoelectric Point: 7.0612

>T29470 WP_003408465.1 NC_021251:c1941583-1941194 [Mycobacterium tuberculosis CCDC5079]
VIVLDASAAVELMLTTPAGAAVARRLRGETVHAPAHFDVEVIGAIRQAVVRQLISDHEGLVVVVNFLSLPVRRWPLKPFT
QRAYQLRSTHTVADGAYVALAEGLGVPLITCDGRLAQSHGHNAEIELVA

Download         Length: 390 bp

>T29470 NC_021251:c1941583-1941194 [Mycobacterium tuberculosis CCDC5079]
GTGATCGTGTTGGACGCCTCGGCGGCCGTCGAGCTCATGCTCACGACGCCGGCGGGTGCGGCGGTCGCCCGGCGCTTGCG
GGGCGAAACCGTGCACGCCCCTGCACATTTCGATGTCGAGGTGATCGGGGCGATACGTCAAGCGGTCGTGCGTCAGCTGA
TCAGCGATCATGAAGGACTCGTCGTGGTTGTCAACTTCCTTAGCCTGCCCGTTCGGCGTTGGCCGTTAAAGCCATTCACC
CAGCGTGCCTACCAACTTCGGTCCACTCATACCGTGGCCGATGGAGCCTACGTCGCCCTCGCCGAGGGCCTCGGCGTACC
GCTTATCACTTGCGACGGGCGACTTGCCCAATCCCATGGCCATAATGCGGAGATCGAGCTTGTCGCCTGA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8226.39 Da        Isoelectric Point: 4.3313

>AT29470 WP_003408469.1 NC_021251:c1941807-1941580 [Mycobacterium tuberculosis CCDC5079]
MSAMVQIRNVPDELLHELKARAAAQRMSLSDFLLARLAEIAEEPALDDVLDRLAALPRRDLGASAAELVDEARSE

Download         Length: 228 bp

>AT29470 NC_021251:c1941807-1941580 [Mycobacterium tuberculosis CCDC5079]
ATGTCCGCCATGGTTCAGATCCGCAACGTTCCCGACGAGCTTCTCCACGAGCTGAAGGCCCGCGCAGCGGCGCAACGGAT
GAGCCTGAGCGATTTCCTCCTAGCACGGCTTGCCGAGATCGCGGAAGAACCGGCCCTCGACGACGTTCTCGACCGTCTAG
CGGCACTGCCGCGCCGGGATCTCGGCGCGAGCGCAGCCGAGCTTGTTGACGAGGCTCGATCTGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4BUI9

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4FAN9

References