Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | mazEF/PRK09907(toxin) |
Location | 501501..502072 | Replicon | chromosome |
Accession | NZ_OU015708 | ||
Organism | Enterococcus faecium isolate USZ_VRE32_P32 |
Toxin (Protein)
Gene name | mazF | Uniprot ID | Q3Y2B8 |
Locus tag | KKQ93_RS02390 | Protein ID | WP_002286801.1 |
Coordinates | 501731..502072 (+) | Length | 114 a.a. |
Antitoxin (Protein)
Gene name | mazE | Uniprot ID | A0A828ZZN9 |
Locus tag | KKQ93_RS02385 | Protein ID | WP_002323011.1 |
Coordinates | 501501..501731 (+) | Length | 77 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
KKQ93_RS02355 | 496634..497965 | + | 1332 | WP_002286818.1 | FAD-containing oxidoreductase | - |
KKQ93_RS02360 | 497987..498613 | + | 627 | WP_002286816.1 | cysteine hydrolase | - |
KKQ93_RS02365 | 498796..499377 | + | 582 | WP_002286813.1 | TetR/AcrR family transcriptional regulator | - |
KKQ93_RS16275 | 500109..500671 | + | 563 | Protein_470 | SOS response-associated peptidase family protein | - |
KKQ93_RS02380 | 500876..501214 | - | 339 | WP_002286804.1 | hypothetical protein | - |
KKQ93_RS02385 | 501501..501731 | + | 231 | WP_002323011.1 | hypothetical protein | Antitoxin |
KKQ93_RS02390 | 501731..502072 | + | 342 | WP_002286801.1 | type II toxin-antitoxin system PemK/MazF family toxin | Toxin |
KKQ93_RS02395 | 502922..503107 | + | 186 | WP_002304207.1 | hypothetical protein | - |
KKQ93_RS02400 | 503612..503806 | + | 195 | WP_002297028.1 | hypothetical protein | - |
KKQ93_RS02405 | 503997..504246 | + | 250 | Protein_476 | transposase | - |
KKQ93_RS02410 | 504490..505320 | - | 831 | WP_002286789.1 | manganese catalase family protein | - |
KKQ93_RS02415 | 505528..506862 | + | 1335 | WP_002286788.1 | ABC transporter substrate-binding protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
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Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 114 a.a. Molecular weight: 13302.68 Da Isoelectric Point: 9.9044
>T294687 WP_002286801.1 NZ_OU015708:501731-502072 [Enterococcus faecium]
VSEERIYIPKKGDIVWIDFDPSVGKEIQKRRPGLVVSRYEFNRKTMFSVICPITSTIKNLPTRYSLPEELDIKGQVIITQ
LKSLDFKERKLKKIENLPLQDMAKIDQIIQYMF
VSEERIYIPKKGDIVWIDFDPSVGKEIQKRRPGLVVSRYEFNRKTMFSVICPITSTIKNLPTRYSLPEELDIKGQVIITQ
LKSLDFKERKLKKIENLPLQDMAKIDQIIQYMF
Download Length: 342 bp
Antitoxin
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A829FD66 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A828ZZN9 |