Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | omega-epsilon-zeta/zeta-epsilon |
Location | 1995..3132 | Replicon | plasmid P03 |
Accession | NZ_OU015353 | ||
Organism | Enterococcus faecium strain AUS2002 isolate AUS2002 |
Toxin (Protein)
Gene name | zeta | Uniprot ID | Q54944 |
Locus tag | K3T69_RS15805 | Protein ID | WP_001284311.1 |
Coordinates | 2269..3132 (+) | Length | 288 a.a. |
Antitoxin (Protein)
Gene name | epsilon | Uniprot ID | R2XCR7 |
Locus tag | K3T69_RS15800 | Protein ID | WP_000301765.1 |
Coordinates | 1995..2267 (+) | Length | 91 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
K3T69_RS15780 | 1..603 | + | 603 | Protein_0 | replication initiation factor domain-containing protein | - |
K3T69_RS15785 | 678..1358 | + | 681 | WP_001015311.1 | IS6-like element IS1216 family transposase | - |
K3T69_RS15790 | 1414..1671 | + | 258 | Protein_2 | chromosome partitioning protein ParA | - |
K3T69_RS15795 | 1763..1978 | + | 216 | WP_001835296.1 | peptide-binding protein | - |
K3T69_RS15800 | 1995..2267 | + | 273 | WP_000301765.1 | antitoxin | Antitoxin |
K3T69_RS15805 | 2269..3132 | + | 864 | WP_001284311.1 | zeta toxin family protein | Toxin |
K3T69_RS15810 | 3395..4132 | - | 738 | WP_001038796.1 | 23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(B) | - |
K3T69_RS15815 | 4257..4340 | - | 84 | WP_031929417.1 | 23S rRNA methyltransferase attenuator leader peptide ErmL | - |
K3T69_RS15825 | 4882..5676 | - | 795 | WP_001096887.1 | aminoglycoside O-phosphotransferase APH(3')-IIIa | - |
K3T69_RS15830 | 5769..6020 | - | 252 | Protein_9 | GNAT family N-acetyltransferase | - |
K3T69_RS15835 | 6265..7560 | + | 1296 | WP_002297218.1 | ISL3-like element ISEfa11 family transposase | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Non-Mobilizable plasmid | erm(B) / aph(3')-III / ant(6)-Ia / lnu(B) / lsa(E) | - | 1..37193 | 37193 | |
- | inside | IScluster/Tn | erm(B) / aph(3')-III / ant(6)-Ia / lnu(B) / lsa(E) | - | 672..36037 | 35365 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 288 a.a. Molecular weight: 32404.02 Da Isoelectric Point: 6.9964
>T294683 WP_001284311.1 NZ_OU015353:2269-3132 [Enterococcus faecium]
MANIVNFTDKQFENRLNDNLEELIQGKKAVESPTAFLLGGQPGSGKTSLRSAIFEETQGNVIVIDNDTFKQQHPNFDELV
KLYEKDVVKHVTPYSNRMTEAIISRLSDQGYNLVIEGTGRTTDVPIQTATMLQAKGYETKMYVMAVPKINSYLGTIERYE
TMYADDPMTARATPKQAHDIVVKNLPTNLETLHKTGLFSDIRLYNREGVKLYSSLETPSISPKETLEKELNRKVSGKEIQ
PTLERIEQKMVLNKHQETPEFKAIQQKLESLQPPTPPIPKTPKLPGI
MANIVNFTDKQFENRLNDNLEELIQGKKAVESPTAFLLGGQPGSGKTSLRSAIFEETQGNVIVIDNDTFKQQHPNFDELV
KLYEKDVVKHVTPYSNRMTEAIISRLSDQGYNLVIEGTGRTTDVPIQTATMLQAKGYETKMYVMAVPKINSYLGTIERYE
TMYADDPMTARATPKQAHDIVVKNLPTNLETLHKTGLFSDIRLYNREGVKLYSSLETPSISPKETLEKELNRKVSGKEIQ
PTLERIEQKMVLNKHQETPEFKAIQQKLESLQPPTPPIPKTPKLPGI
Download Length: 864 bp
Antitoxin
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
PDB | 1GVN | |
PDB | 3Q8X |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A829F0A3 |