Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 1689598..1690214 Replicon chromosome
Accession NC_021251
Organism Mycobacterium tuberculosis CCDC5079

Toxin (Protein)


Gene name mazF Uniprot ID G0TJ74
Locus tag CFBS_RS07965 Protein ID WP_003407593.1
Coordinates 1689897..1690214 (+) Length 106 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID G0TJ73
Locus tag CFBS_RS07960 Protein ID WP_003900349.1
Coordinates 1689598..1689900 (+) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CFBS_RS07950 1685484..1687331 + 1848 WP_003407585.1 methylmalonyl-CoA mutase small subunit -
CFBS_RS07955 1687332..1689584 + 2253 WP_003407587.1 methylmalonyl-CoA mutase -
CFBS_RS07960 1689598..1689900 + 303 WP_003900349.1 type II toxin-antitoxin system antitoxin MazE4 Antitoxin
CFBS_RS07965 1689897..1690214 + 318 WP_003407593.1 type II toxin-antitoxin system toxin endoribonuclease MazF4 Toxin
CFBS_RS07970 1690211..1691215 + 1005 WP_003407596.1 methylmalonyl Co-A mutase-associated GTPase MeaB -
CFBS_RS07975 1691268..1692557 + 1290 WP_003902090.1 serine hydrolase -
CFBS_RS07980 1692630..1693403 - 774 WP_003912632.1 class I SAM-dependent methyltransferase -
CFBS_RS07985 1693461..1693673 - 213 WP_003898900.1 dodecin family protein -
CFBS_RS22605 1693683..1693907 - 225 WP_160522526.1 NUDIX domain-containing protein -
CFBS_RS07995 1694177..1695205 + 1029 WP_003407612.1 glycosyltransferase family 2 protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(6-99)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 11377.97 Da        Isoelectric Point: 7.9950

>T29468 WP_003407593.1 NC_021251:1689897-1690214 [Mycobacterium tuberculosis CCDC5079]
VNAPLRGQVYRCDLGYGAKPWLIVSNNARNRHTADVVAVRLTTTRRTIPTWVAMGPSDPLTGYVNADNIETLGKDELGDY
LGEVTPATMNKINTALATALGLPWP

Download         Length: 318 bp

>T29468 NC_021251:1689897-1690214 [Mycobacterium tuberculosis CCDC5079]
GTGAACGCGCCGTTGCGTGGTCAGGTCTATCGATGCGACCTCGGATACGGGGCCAAACCGTGGCTCATCGTCTCCAACAA
CGCCCGCAACCGTCACACCGCCGACGTGGTGGCTGTGCGCCTGACAACAACGCGGAGAACCATACCGACCTGGGTCGCCA
TGGGCCCCAGCGATCCATTGACCGGATACGTCAACGCGGACAACATCGAGACCCTCGGCAAAGACGAGCTCGGTGACTAC
CTCGGTGAGGTCACGCCGGCGACGATGAACAAAATCAACACGGCGCTCGCGACCGCGCTGGGGCTACCGTGGCCATGA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11173.42 Da        Isoelectric Point: 9.5564

>AT29468 WP_003900349.1 NC_021251:1689598-1689900 [Mycobacterium tuberculosis CCDC5079]
VPFLVALSGIISGVRDHSMTVRLDQQTRQRLQDIVKGGYRSANAAIVDAINKRWEALHDEQLDAAYAAAIHDNPAYPYES
EAERSAARARRNARQQRSAQ

Download         Length: 303 bp

>AT29468 NC_021251:1689598-1689900 [Mycobacterium tuberculosis CCDC5079]
GTGCCGTTTCTGGTTGCATTATCCGGTATCATCTCGGGCGTGCGTGATCATTCGATGACCGTGCGGCTCGACCAGCAAAC
TCGCCAGCGCCTGCAAGACATTGTGAAAGGCGGATACCGGAGCGCTAATGCGGCGATCGTCGACGCCATCAACAAGCGCT
GGGAGGCGCTACACGATGAGCAACTCGACGCCGCCTACGCGGCCGCGATCCATGACAATCCGGCGTACCCGTACGAGTCT
GAGGCCGAACGGAGCGCCGCGCGGGCCCGGCGCAACGCCAGGCAGCAGCGCTCGGCACAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 5XE3
PDB 5XE2

Antitoxin

Source ID Structure
PDB 5XE3
AlphaFold DB G0TJ73

References