Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-yefM/Txe-RelB
Location 186115..186644 Replicon chromosome
Accession NZ_OU015350
Organism Enterococcus faecium strain AUS2002 isolate AUS2002

Toxin (Protein)


Gene name relE Uniprot ID Q3XX67
Locus tag K3T69_RS00920 Protein ID WP_002296560.1
Coordinates 186378..186644 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A829F3T0
Locus tag K3T69_RS00915 Protein ID WP_002296559.1
Coordinates 186115..186378 (+) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K3T69_RS00905 183489..185312 + 1824 WP_002294202.1 APC family permease -
K3T69_RS00910 185454..185639 - 186 WP_002296558.1 transcriptional regulator -
K3T69_RS00915 186115..186378 + 264 WP_002296559.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
K3T69_RS00920 186378..186644 + 267 WP_002296560.1 Txe/YoeB family addiction module toxin Toxin
K3T69_RS00925 186845..187333 + 489 WP_002296561.1 mannosyl-glycoprotein endo-beta-N-acetylglucosamidase -
K3T69_RS00930 187874..188527 - 654 WP_002323018.1 ABC transporter permease -
K3T69_RS00935 188542..189459 - 918 WP_002302664.1 osmoprotectant ABC transporter substrate-binding protein -
K3T69_RS00940 189456..190097 - 642 WP_002293405.1 ABC transporter permease -
K3T69_RS00945 190101..191276 - 1176 WP_002294192.1 betaine/proline/choline family ABC transporter ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(9-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(5-69)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10660.13 Da        Isoelectric Point: 9.9931

>T294679 WP_002296560.1 NZ_OU015350:186378-186644 [Enterococcus faecium]
MSNYTVAIKNSAKVDLRKIKQTNLKKQFEEVIQTLKEDPYMPTQSFEKLRPTHEGRYSRRLNRQHRVVYKVDEENKVVEI
YSAWTHYE

Download         Length: 267 bp

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 10046.05 Da        Isoelectric Point: 4.1207

>AT294679 WP_002296559.1 NZ_OU015350:186115-186378 [Enterococcus faecium]
MANTTMNPSTARKNFYQLLKEVNENHTEIEIISDRSGNNAVLIGLEDWRAIQETLFLEQTGTLDKVRDREKDDSSFTNID
DIDWEAL

Download         Length: 264 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829FCW8

Antitoxin

Source ID Structure
AlphaFold DB A0A829F3T0

References