Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 4439792..4440573 Replicon chromosome
Accession NZ_OU015342
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain AUSMDU00007171 isolate AUSMDU00007171

Toxin (Protein)


Gene name TacT2 Uniprot ID E8X9W8
Locus tag KKQ83_RS21705 Protein ID WP_000626099.1
Coordinates 4439792..4440283 (-) Length 164 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID B5R979
Locus tag KKQ83_RS21710 Protein ID WP_001110452.1
Coordinates 4440280..4440573 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KKQ83_RS21665 (4434978) 4434978..4435220 - 243 WP_197603740.1 hypothetical protein -
KKQ83_RS21670 (4435217) 4435217..4435573 - 357 WP_033567083.1 hypothetical protein -
KKQ83_RS21675 (4435570) 4435570..4436442 - 873 WP_033567082.1 ParA family protein -
KKQ83_RS21680 (4436633) 4436633..4436710 - 78 Protein_4265 helix-turn-helix domain-containing protein -
KKQ83_RS21685 (4436801) 4436801..4437133 - 333 WP_001165471.1 MerR family transcriptional regulator -
KKQ83_RS21690 (4437205) 4437205..4437582 + 378 WP_000916345.1 EthD family reductase -
KKQ83_RS21695 (4438615) 4438615..4438689 + 75 Protein_4268 porin family protein -
KKQ83_RS21700 (4438792) 4438792..4439544 + 753 WP_000842434.1 non-specific acid phosphatase -
KKQ83_RS21705 (4439792) 4439792..4440283 - 492 WP_000626099.1 GNAT family N-acetyltransferase Toxin
KKQ83_RS21710 (4440280) 4440280..4440573 - 294 WP_001110452.1 DUF1778 domain-containing protein Antitoxin
KKQ83_RS21715 (4440890) 4440890..4441111 + 222 WP_001576552.1 hypothetical protein -
KKQ83_RS21720 (4441376) 4441376..4442251 + 876 WP_000921674.1 AraC family transcriptional regulator -
KKQ83_RS21725 (4442248) 4442248..4442535 + 288 WP_001269916.1 transcriptional regulator RtsB -
KKQ83_RS21730 (4442558) 4442558..4442773 + 216 WP_001595136.1 hypothetical protein -
KKQ83_RS21735 (4442781) 4442781..4443050 + 270 WP_010989096.1 hypothetical protein -
KKQ83_RS21740 (4443344) 4443344..4444249 - 906 WP_001268200.1 YjiK family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(85-145)

Antitoxin

Vibrio phage ICP1, Orf50

(14-88)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 17646.39 Da        Isoelectric Point: 6.8437

>T294670 WP_000626099.1 NZ_OU015342:c4440283-4439792 [Salmonella enterica subsp. enterica serovar Typhimurium]
MISTPEPLHAGHILTPFCCGVDSIDNWLEQRAMKNQTTGASRTFVCCGSDSNVLAYYSLASSAVTTNTSPGRFRRNMPDP
IPVVVLGRLAVDKSLHGQGVARALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFVPSPMDPMMLMVTLGDLV
ESV

Download         Length: 492 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10977.61 Da        Isoelectric Point: 8.6141

>AT294670 WP_001110452.1 NZ_OU015342:c4440573-4440280 [Salmonella enterica subsp. enterica serovar Typhimurium]
MPAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPEAYQEFLVRLDQTPSPN
AALRKTMQTPAPWEQEK

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7AK7

Antitoxin

Source ID Structure
PDB 7AK7
AlphaFold DB A0A5I1DGA4

References