Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 4121927..4122587 Replicon chromosome
Accession NZ_OU015340
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain AUSMDU00027944 isolate AUSMDU00027944

Toxin (Protein)


Gene name cptA Uniprot ID Q57K70
Locus tag KKR00_RS20800 Protein ID WP_000244756.1
Coordinates 4122174..4122587 (+) Length 138 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S5MU13
Locus tag KKR00_RS20795 Protein ID WP_000351186.1
Coordinates 4121927..4122193 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KKR00_RS20775 (4117855) 4117855..4119288 - 1434 WP_001230141.1 6-phospho-beta-glucosidase BglA -
KKR00_RS20780 (4119447) 4119447..4119758 + 312 WP_001182976.1 N(4)-acetylcytidine aminohydrolase -
KKR00_RS20785 (4119922) 4119922..4120581 + 660 WP_000250289.1 hemolysin III family protein -
KKR00_RS20790 (4120697) 4120697..4121677 - 981 WP_000874172.1 tRNA-modifying protein YgfZ -
KKR00_RS20795 (4121927) 4121927..4122193 + 267 WP_000351186.1 FAD assembly factor SdhE Antitoxin
KKR00_RS20800 (4122174) 4122174..4122587 + 414 WP_000244756.1 protein YgfX Toxin
KKR00_RS20805 (4122640) 4122640..4123161 - 522 WP_001055885.1 flavodoxin FldB -
KKR00_RS20810 (4123274) 4123274..4124170 + 897 WP_000434302.1 site-specific tyrosine recombinase XerD -
KKR00_RS20815 (4124194) 4124194..4124907 + 714 WP_000745625.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
KKR00_RS20820 (4124913) 4124913..4126646 + 1734 WP_000813394.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 16183.15 Da        Isoelectric Point: 10.7537

>T294647 WP_000244756.1 NZ_OU015340:4122174-4122587 [Salmonella enterica subsp. enterica serovar Typhimurium]
VVLWQSDLRVSWRAQWISLLIHGLVAAVILLMPWPLSYTPLWMILLSLVVFDCVRSQRRINTCQGEIKLLMDGRLRWQGQ
DWTLLRPPWLLKSGMVLRLRAESGRHQHLWLAADSMEEAEWRELRRILLQQPISGQH

Download         Length: 414 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10550.05 Da        Isoelectric Point: 6.0783

>AT294647 WP_000351186.1 NZ_OU015340:4121927-4122193 [Salmonella enterica subsp. enterica serovar Typhimurium]
MDIHNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFVRLLQSDDPDLFNWLMNHGKPADAELEQMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Z1E9V5

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0YWH4

References