294623

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 3459898..3460658 Replicon chromosome
Accession NZ_OU015323
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain AUSMDU00004549 isolate AUSMDU00004549

Toxin (Protein)


Gene name tacT Uniprot ID Q57IH1
Locus tag KKQ99_RS17540 Protein ID WP_000533909.1
Coordinates 3460173..3460658 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID M7RHS4
Locus tag KKQ99_RS17535 Protein ID WP_000965886.1
Coordinates 3459898..3460185 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KKQ99_RS17510 (3455338) 3455338..3457407 + 2070 WP_001291736.1 glycine--tRNA ligase subunit beta -
KKQ99_RS17515 (3457589) 3457589..3457864 + 276 Protein_3436 IS3 family transposase -
KKQ99_RS17520 (3457978) 3457978..3458721 - 744 WP_229038580.1 IS3 family transposase -
KKQ99_RS17525 (3458796) 3458796..3459110 - 315 WP_039026396.1 transposase -
KKQ99_RS17530 (3459253) 3459253..3459720 + 468 WP_000702452.1 GNAT family N-acetyltransferase -
KKQ99_RS17535 (3459898) 3459898..3460185 + 288 WP_000965886.1 DUF1778 domain-containing protein Antitoxin
KKQ99_RS17540 (3460173) 3460173..3460658 + 486 WP_000533909.1 GNAT family N-acetyltransferase Toxin
KKQ99_RS17545 (3461030) 3461030..3461569 - 540 WP_000047149.1 copper-binding periplasmic metallochaperone CueP -
KKQ99_RS17550 (3461743) 3461743..3461955 - 213 WP_000014594.1 RNA chaperone/antiterminator CspA -
KKQ99_RS17555 (3462244) 3462244..3462534 - 291 WP_000455790.1 HTH-type transcriptional regulator -
KKQ99_RS17560 (3462973) 3462973..3463683 + 711 WP_000190524.1 DUF3053 domain-containing protein -
KKQ99_RS17565 (3463733) 3463733..3464707 - 975 WP_000804674.1 glyoxylate/hydroxypyruvate reductase GhrB -
KKQ99_RS17570 (3464926) 3464926..3465588 - 663 WP_000747548.1 OmpA family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(31-152)

Antitoxin

Vibrio phage ICP1, Orf50

(5-94)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17703.41 Da        Isoelectric Point: 9.8719

>T294623 WP_000533909.1 NZ_OU015323:3460173-3460658 [Salmonella enterica subsp. enterica serovar Typhimurium]
VGRVTAPEPLSAFHQVAEFVSGEAVLDDWLKQKGLKNQALGAARTFVVCKKDTKQVAGFYSLATGSVNHTEATGNLRRNM
PDPIPVIILARLAVDLSFHGKGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKNFYIHHGFKSSQTQQRTLFLRLP
Q

Download         Length: 486 bp

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10950.60 Da        Isoelectric Point: 4.6811

>AT294623 WP_000965886.1 NZ_OU015323:3459898-3460185 [Salmonella enterica subsp. enterica serovar Typhimurium]
MLYKGCLMKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILETACQAAEKVILDRRVFNFNDEQYEEFINLLDAPVADD
PVIEKLLARKPQWDV

Download         Length: 288 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7F36
PDB 7AK8
PDB 5FVJ

Antitoxin

Source ID Structure
AlphaFold DB A0A3V2JDX2

References