Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 2680107..2680888 Replicon chromosome
Accession NZ_OU015323
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain AUSMDU00004549 isolate AUSMDU00004549

Toxin (Protein)


Gene name TacT2 Uniprot ID E8X9W8
Locus tag KKQ99_RS13695 Protein ID WP_000626099.1
Coordinates 2680107..2680598 (-) Length 164 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID B5R979
Locus tag KKQ99_RS13700 Protein ID WP_001110452.1
Coordinates 2680595..2680888 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KKQ99_RS13655 (2675293) 2675293..2675535 - 243 WP_197603740.1 hypothetical protein -
KKQ99_RS13660 (2675532) 2675532..2675888 - 357 WP_033567083.1 hypothetical protein -
KKQ99_RS13665 (2675885) 2675885..2676757 - 873 WP_033567082.1 ParA family protein -
KKQ99_RS13670 (2676948) 2676948..2677025 - 78 Protein_2692 helix-turn-helix domain-containing protein -
KKQ99_RS13675 (2677116) 2677116..2677448 - 333 WP_001165471.1 MerR family transcriptional regulator -
KKQ99_RS13680 (2677520) 2677520..2677897 + 378 WP_000916345.1 EthD family reductase -
KKQ99_RS13685 (2678930) 2678930..2679004 + 75 Protein_2695 porin family protein -
KKQ99_RS13690 (2679107) 2679107..2679859 + 753 WP_000842434.1 non-specific acid phosphatase -
KKQ99_RS13695 (2680107) 2680107..2680598 - 492 WP_000626099.1 GNAT family N-acetyltransferase Toxin
KKQ99_RS13700 (2680595) 2680595..2680888 - 294 WP_001110452.1 DUF1778 domain-containing protein Antitoxin
KKQ99_RS13705 (2681205) 2681205..2681426 + 222 WP_001576552.1 hypothetical protein -
KKQ99_RS13710 (2681691) 2681691..2682566 + 876 WP_000921674.1 AraC family transcriptional regulator -
KKQ99_RS13715 (2682563) 2682563..2682850 + 288 WP_001269916.1 transcriptional regulator RtsB -
KKQ99_RS13720 (2682873) 2682873..2683088 + 216 WP_001595136.1 hypothetical protein -
KKQ99_RS13725 (2683096) 2683096..2683365 + 270 WP_010989096.1 hypothetical protein -
KKQ99_RS13730 (2683659) 2683659..2684564 - 906 WP_001268200.1 YjiK family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(85-145)

Antitoxin

Vibrio phage ICP1, Orf50

(14-88)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 17646.39 Da        Isoelectric Point: 6.8437

>T294620 WP_000626099.1 NZ_OU015323:c2680598-2680107 [Salmonella enterica subsp. enterica serovar Typhimurium]
MISTPEPLHAGHILTPFCCGVDSIDNWLEQRAMKNQTTGASRTFVCCGSDSNVLAYYSLASSAVTTNTSPGRFRRNMPDP
IPVVVLGRLAVDKSLHGQGVARALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFVPSPMDPMMLMVTLGDLV
ESV

Download         Length: 492 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10977.61 Da        Isoelectric Point: 8.6141

>AT294620 WP_001110452.1 NZ_OU015323:c2680888-2680595 [Salmonella enterica subsp. enterica serovar Typhimurium]
MPAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPEAYQEFLVRLDQTPSPN
AALRKTMQTPAPWEQEK

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7AK7

Antitoxin

Source ID Structure
PDB 7AK7
AlphaFold DB A0A5I1DGA4

References