29462

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 1229389..1230020 Replicon chromosome
Accession NC_021251
Organism Mycobacterium tuberculosis CCDC5079

Toxin (Protein)


Gene name mazF Uniprot ID A0A7U4F9D0
Locus tag CFBS_RS05860 Protein ID WP_003405820.1
Coordinates 1229389..1229700 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID G0TGZ7
Locus tag CFBS_RS05865 Protein ID WP_003405836.1
Coordinates 1229700..1230020 (-) Length 107 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CFBS_RS05840 1224870..1226294 - 1425 WP_003405805.1 class II fumarate hydratase -
CFBS_RS05845 1226325..1227413 - 1089 WP_003898726.1 class II fructose-bisphosphatase -
CFBS_RS05850 1227469..1228113 + 645 WP_003915494.1 DUF4245 domain-containing protein -
CFBS_RS05855 1228120..1229277 - 1158 WP_003898727.1 AI-2E family transporter -
CFBS_RS05860 1229389..1229700 - 312 WP_003405820.1 type II toxin-antitoxin system toxin endoribonuclease MazF3 Toxin
CFBS_RS05865 1229700..1230020 - 321 WP_003405836.1 type II toxin-antitoxin system antitoxin MazE3 Antitoxin
CFBS_RS21120 1230030..1231555 + 1526 Protein_1143 carboxylesterase/lipase family protein -
CFBS_RS05880 1231573..1232685 - 1113 WP_003405840.1 3 beta-hydroxysteroid dehydrogenase/delta 5-->4-isomerase -
CFBS_RS05885 1232695..1232952 - 258 WP_003405844.1 exodeoxyribonuclease VII small subunit -
CFBS_RS05890 1232942..1234189 - 1248 WP_003405846.1 exodeoxyribonuclease VII large subunit -
CFBS_RS05895 1234186..1234824 - 639 WP_003898730.1 lipid droplet-associated protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-85)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 11061.82 Da        Isoelectric Point: 4.9371

>T29462 WP_003405820.1 NC_021251:c1229700-1229389 [Mycobacterium tuberculosis CCDC5079]
MRPIHIAQLDKARPVLILTREVVRPHLTNVTVAPITTTVRGLATEVPVDAVNGLNQPSVVSCDNIQTIPVCDLGRQIGYL
LASQEPALAEAIGNAFDLDWVVA

Download         Length: 312 bp

>T29462 NC_021251:c1229700-1229389 [Mycobacterium tuberculosis CCDC5079]
ATGCGACCTATCCACATCGCACAGCTTGACAAGGCTAGACCCGTCCTGATCCTTACCCGCGAGGTCGTACGTCCGCACCT
CACGAACGTCACCGTCGCCCCGATCACGACAACCGTGCGTGGGCTAGCCACCGAAGTCCCGGTAGACGCGGTGAACGGGC
TGAATCAACCGTCAGTCGTCAGCTGCGACAACATCCAAACGATCCCGGTGTGTGACCTTGGTCGTCAAATCGGCTACCTG
CTCGCGTCGCAGGAGCCGGCTCTAGCCGAGGCCATCGGCAACGCGTTCGACCTCGATTGGGTGGTGGCATAG

Antitoxin


Download         Length: 107 a.a.        Molecular weight: 11394.83 Da        Isoelectric Point: 5.1236

>AT29462 WP_003405836.1 NC_021251:c1230020-1229700 [Mycobacterium tuberculosis CCDC5079]
MYLPWGVVLAGGANGFGAGAYQTGTICEVSTQIAVRLPDEIVAFIDDEVRGQHARSRAAVVLRALERERRRRLAERDAEI
LATNTSATGDLDTLAGHCARTALDID

Download         Length: 321 bp

>AT29462 NC_021251:c1230020-1229700 [Mycobacterium tuberculosis CCDC5079]
ATGTACCTACCCTGGGGGGTCGTCCTCGCCGGCGGCGCGAACGGTTTTGGGGCGGGTGCATACCAAACTGGTACCATCTG
TGAAGTGAGTACACAGATTGCGGTTCGCTTGCCCGATGAGATTGTCGCGTTCATCGACGACGAAGTCCGGGGACAGCATG
CCCGTAGCCGTGCGGCTGTCGTGCTGCGGGCGCTGGAACGGGAACGCCGCCGTCGTCTCGCCGAACGCGACGCGGAGATC
CTCGCCACCAACACGTCAGCCACGGGTGATCTGGATACGCTGGCCGGCCACTGCGCTCGTACCGCCCTCGACATCGACTG
A

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4F9D0

Antitoxin

Source ID Structure
AlphaFold DB G0TGZ7

References