294619

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 2471314..2471830 Replicon chromosome
Accession NZ_OU015323
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain AUSMDU00004549 isolate AUSMDU00004549

Toxin (Protein)


Gene name relE Uniprot ID C0Q7A9
Locus tag KKQ99_RS12585 Protein ID WP_000220578.1
Coordinates 2471314..2471598 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID V7ISI8
Locus tag KKQ99_RS12590 Protein ID WP_000212724.1
Coordinates 2471588..2471830 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KKQ99_RS12570 (2466526) 2466526..2468178 + 1653 WP_000155057.1 alpha,alpha-phosphotrehalase -
KKQ99_RS12575 (2468587) 2468587..2470725 + 2139 WP_000187818.1 anaerobic ribonucleoside-triphosphate reductase -
KKQ99_RS12580 (2470846) 2470846..2471310 + 465 WP_001268859.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
KKQ99_RS12585 (2471314) 2471314..2471598 - 285 WP_000220578.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
KKQ99_RS12590 (2471588) 2471588..2471830 - 243 WP_000212724.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
KKQ99_RS12595 (2471908) 2471908..2473821 - 1914 WP_001212137.1 BglG family transcription antiterminator -
KKQ99_RS12600 (2473838) 2473838..2474578 - 741 WP_000779263.1 KDGP aldolase family protein -
KKQ99_RS12605 (2474575) 2474575..2475693 - 1119 WP_001139182.1 DgaE family pyridoxal phosphate-dependent ammonia lyase -
KKQ99_RS12610 (2475677) 2475677..2476810 - 1134 WP_000459930.1 amidohydrolase/deacetylase family metallohydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10854.67 Da        Isoelectric Point: 10.0482

>T294619 WP_000220578.1 NZ_OU015323:c2471598-2471314 [Salmonella enterica subsp. enterica serovar Typhimurium]
MTYELEFDPRALKEWHKLGDTVKAQLKKKLADVLLNPRIDSARLNGLPDCYKIKLKSSGYRLVYQVRDDVVIVFVVAVGK
REHSAVYHDANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.34 Da        Isoelectric Point: 5.0651

>AT294619 WP_000212724.1 NZ_OU015323:c2471830-2471588 [Salmonella enterica subsp. enterica serovar Typhimurium]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTLSDSEDALIQTVRERLSSPQKGIKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Z1E876

Antitoxin

Source ID Structure
AlphaFold DB A0A5H5JRI5

References