294618

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) shpAB/BrnT-BrnA
Location 2388357..2388933 Replicon chromosome
Accession NZ_OU015323
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain AUSMDU00004549 isolate AUSMDU00004549

Toxin (Protein)


Gene name shpA Uniprot ID M7RG88
Locus tag KKQ99_RS12220 Protein ID WP_001131963.1
Coordinates 2388646..2388933 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name shpB Uniprot ID B5R9R5
Locus tag KKQ99_RS12215 Protein ID WP_000063142.1
Coordinates 2388357..2388659 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KKQ99_RS12200 (2384867) 2384867..2387017 + 2151 WP_000379927.1 pyruvate/proton symporter BtsT -
KKQ99_RS12205 (2387112) 2387112..2387315 + 204 WP_000460616.1 YbdD/YjiX family protein -
KKQ99_RS12210 (2387326) 2387326..2388282 + 957 WP_000187839.1 GTPase -
KKQ99_RS12215 (2388357) 2388357..2388659 - 303 WP_000063142.1 BrnA antitoxin family protein Antitoxin
KKQ99_RS12220 (2388646) 2388646..2388933 - 288 WP_001131963.1 BrnT family toxin Toxin
KKQ99_RS12225 (2389202) 2389202..2390116 - 915 WP_000290512.1 restriction endonuclease -
KKQ99_RS12230 (2390314) 2390314..2393823 + 3510 WP_001043484.1 type I restriction-modification system endonuclease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(7-88)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(37-93)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11294.80 Da        Isoelectric Point: 9.5894

>T294618 WP_001131963.1 NZ_OU015323:c2388933-2388646 [Salmonella enterica subsp. enterica serovar Typhimurium]
MPMEFEWDANKAKSNLRKHGVRFEDAVLVFDDPRHLSRQERYENGEYRWQTLGLVHGIVVILVAHSVRFESGFEVIRIIS
ARKADRKERNRYEHG

Download         Length: 288 bp

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11373.96 Da        Isoelectric Point: 10.1293

>AT294618 WP_000063142.1 NZ_OU015323:c2388659-2388357 [Salmonella enterica subsp. enterica serovar Typhimurium]
MSMVKHKRGNASALSAQHEAELKALAKKSDDEIDYSDIPASEDGQWSEAVRGKFFRPLKTQASVRIDADVMEWLKRPGKG
YQTRLNAILREAMLREQNKK

Download         Length: 303 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7VD7

Antitoxin

Source ID Structure
AlphaFold DB A0A4D6PB01

References