294615

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1743619..1744239 Replicon chromosome
Accession NZ_OU015323
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain AUSMDU00004549 isolate AUSMDU00004549

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag KKQ99_RS09045 Protein ID WP_001280991.1
Coordinates 1744021..1744239 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag KKQ99_RS09040 Protein ID WP_000344807.1
Coordinates 1743619..1743993 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KKQ99_RS09025 (1738757) 1738757..1741906 + 3150 WP_001132508.1 efflux RND transporter permease AcrB -
KKQ99_RS09030 (1742398) 1742398..1742712 + 315 WP_039026396.1 transposase -
KKQ99_RS09035 (1742787) 1742787..1743530 + 744 WP_229038580.1 IS3 family transposase -
KKQ99_RS09040 (1743619) 1743619..1743993 + 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
KKQ99_RS09045 (1744021) 1744021..1744239 + 219 WP_001280991.1 HHA domain-containing protein Toxin
KKQ99_RS09050 (1744418) 1744418..1744969 + 552 WP_001278792.1 maltose O-acetyltransferase -
KKQ99_RS09055 (1745086) 1745086..1745556 + 471 WP_000136181.1 YlaC family protein -
KKQ99_RS09060 (1745612) 1745612..1745752 - 141 WP_001197749.1 type B 50S ribosomal protein L36 -
KKQ99_RS09065 (1745758) 1745758..1746018 - 261 WP_000801415.1 type B 50S ribosomal protein L31 -
KKQ99_RS09070 (1746243) 1746243..1747793 + 1551 WP_000213139.1 EAL domain-containing protein -
KKQ99_RS09080 (1748024) 1748024..1748413 + 390 WP_000961285.1 MGMT family protein -
KKQ99_RS09085 (1748446) 1748446..1749015 - 570 WP_000779803.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T294615 WP_001280991.1 NZ_OU015323:1744021-1744239 [Salmonella enterica subsp. enterica serovar Typhimurium]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT294615 WP_000344807.1 NZ_OU015323:1743619-1743993 [Salmonella enterica subsp. enterica serovar Typhimurium]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References