294586

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) omega-epsilon-zeta/zeta-epsilon
Location 432128..432710 Replicon chromosome
Accession NZ_OD940440
Organism Enterococcus faecalis isolate WE0254

Toxin (Protein)


Gene name zeta Uniprot ID A0A0M2AE74
Locus tag KG893_RS02265 Protein ID WP_002355414.1
Coordinates 432402..432710 (+) Length 103 a.a.

Antitoxin (Protein)


Gene name epsilon Uniprot ID Q9AL19
Locus tag KG893_RS02260 Protein ID WP_002326825.1
Coordinates 432128..432400 (+) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KG893_RS02230 (427409) 427409..428137 - 729 WP_002355404.1 GntR family transcriptional regulator -
KG893_RS02235 (428314) 428314..429240 + 927 WP_002355406.1 hypothetical protein -
KG893_RS02240 (429257) 429257..430540 + 1284 WP_002363033.1 PTS sugar transporter subunit IIC -
KG893_RS02245 (430732) 430732..430854 + 123 Protein_421 topoisomerase -
KG893_RS02250 (430929) 430929..431825 + 897 WP_002363034.1 ParA family protein -
KG893_RS02255 (431902) 431902..432111 + 210 WP_002363035.1 peptide-binding protein -
KG893_RS02260 (432128) 432128..432400 + 273 WP_002326825.1 antitoxin Antitoxin
KG893_RS02265 (432402) 432402..432710 + 309 WP_002355414.1 zeta toxin family protein Toxin
KG893_RS02270 (432790) 432790..433212 - 423 WP_080005963.1 tyrosine-type recombinase/integrase -
KG893_RS02275 (433263) 433263..433763 - 501 WP_002363039.1 HAD family hydrolase -
KG893_RS02280 (433768) 433768..434535 - 768 WP_002355416.1 DeoR/GlpR family DNA-binding transcription regulator -
KG893_RS02285 (435023) 435023..435448 + 426 WP_002355418.1 galactose-6-phosphate isomerase subunit LacA -
KG893_RS02290 (435465) 435465..435980 + 516 WP_002345825.1 galactose-6-phosphate isomerase subunit LacB -
KG893_RS02295 (435991) 435991..436923 + 933 WP_002363040.1 tagatose-6-phosphate kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 414192..447458 33266


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Zeta toxin domain

(27-99)

Antitoxin

Bacterial epsilon antitoxin

(2-90)


Sequences

Toxin        


Download         Length: 103 a.a.        Molecular weight: 11525.91 Da        Isoelectric Point: 5.7251

>T294586 WP_002355414.1 NZ_OD940440:432402-432710 [Enterococcus faecalis]
MANITDFTEKQFEDRLEKNVERLTKNRLAVESPTAFLLGGQPGSGKTSLRSAISEETQGNVVIIDNDTFKQQHPNFDELV
KLYEKDVVKHATSYSNQLVKLN

Download         Length: 309 bp

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 10720.17 Da        Isoelectric Point: 4.4865

>AT294586 WP_002326825.1 NZ_OD940440:432128-432400 [Enterococcus faecalis]
MAVTYEKTFEIEIINELSASVYNRVLNYVLNHELDTKNTRLLEVNLLNQLEVAQEVDLFQQPFEELQAIHEYWRSMNQYS
KQILTKEKVA

Download         Length: 273 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0M2AE74

Antitoxin

Source ID Structure
AlphaFold DB A0A0M2AF93

References