294572

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) omega-epsilon-zeta/zeta-epsilon
Location 1524108..1525245 Replicon chromosome
Accession NZ_OD940437
Organism Enterococcus faecalis isolate BX8117

Toxin (Protein)


Gene name zeta Uniprot ID -
Locus tag KJA90_RS07350 Protein ID WP_002401483.1
Coordinates 1524108..1524971 (-) Length 288 a.a.

Antitoxin (Protein)


Gene name epsilon Uniprot ID R2XCR7
Locus tag KJA90_RS07355 Protein ID WP_000301765.1
Coordinates 1524973..1525245 (-) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KJA90_RS07320 (1520024) 1520024..1520791 - 768 WP_002357481.1 ribonuclease HII -
KJA90_RS07325 (1520793) 1520793..1521644 - 852 WP_002357480.1 ribosome biogenesis GTPase YlqF -
KJA90_RS07330 (1521920) 1521920..1522234 - 315 Protein_1417 ketopantoate reductase C-terminal domain-containing protein -
KJA90_RS07335 (1522289) 1522289..1522969 - 681 WP_010710189.1 IS6-like element IS1216 family transposase -
KJA90_RS07340 (1523043) 1523043..1523330 - 288 Protein_1419 DnaJ domain-containing protein -
KJA90_RS07345 (1523350) 1523350..1523667 - 318 WP_002333463.1 hypothetical protein -
KJA90_RS07350 (1524108) 1524108..1524971 - 864 WP_002401483.1 zeta toxin family protein Toxin
KJA90_RS07355 (1524973) 1524973..1525245 - 273 WP_000301765.1 antitoxin Antitoxin
KJA90_RS07360 (1525262) 1525262..1525477 - 216 WP_002295735.1 peptide-binding protein -
KJA90_RS07365 (1525576) 1525576..1526472 - 897 WP_002387620.1 ParA family protein -
KJA90_RS07370 (1526575) 1526575..1526835 - 261 Protein_1425 topoisomerase DNA-binding C4 zinc finger domain-containing protein -
KJA90_RS07375 (1527005) 1527005..1527742 - 738 WP_002292226.1 23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(B) -
KJA90_RS07380 (1527867) 1527867..1527962 - 96 WP_001809736.1 23S rRNA methyltransferase attenuation leader peptide -
KJA90_RS07385 (1528031) 1528031..1528153 - 123 Protein_1428 peptide-binding protein -
KJA90_RS07390 (1528273) 1528273..1529949 - 1677 WP_002346508.1 type IA DNA topoisomerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside IScluster/Tn erm(B) / cat / str - 1522289..1535513 13224


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Zeta toxin domain

(27-213)

Antitoxin

Bacterial epsilon antitoxin

(2-90)


Sequences

Toxin        


Download         Length: 288 a.a.        Molecular weight: 32486.06 Da        Isoelectric Point: 6.9965

>T294572 WP_002401483.1 NZ_OD940437:c1524971-1524108 [Enterococcus faecalis]
MANIVNFTDKQFENRLNDNLEELIQGKKAVESPTAFLLGGQPGSGKTSLRSAILEETQGNVIVIDNDTFKQQHPNFDELA
KLYEKDVVKHVTPYSNRMTEAIISRLSDQGYNLVIEGTGRTTDVPIQTATMLQAKGYETKMYVMAVPKINSYLGTIERYE
TMYADDPMTARATPKQAHDIVVKNLPTNLETLHKTGLFSDIRLYNREGVKLYSRLETPSISPKETLERELNRKVSGKEIQ
PTLERIEQKMLQNQHQETPEFKAIQQKMESLQPPTPPIPKTPKLPGL

Download         Length: 864 bp

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 10721.25 Da        Isoelectric Point: 6.4676

>AT294572 WP_000301765.1 NZ_OD940437:c1525245-1524973 [Enterococcus faecalis]
MAVTYEKTFEIEIINELSASVYNRVLNYVLNHELNKNDSQLLEVNLLNQLKLAKRVNLFDYSLEELQAVHEYWRSMNRYS
KQVLNKEKVA

Download         Length: 273 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A829F0A3

References