Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907(toxin)
Location 2690407..2690978 Replicon chromosome
Accession NZ_OD940434
Organism Enterococcus faecalis isolate BX5936

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag KJA96_RS12945 Protein ID WP_002354774.1
Coordinates 2690407..2690748 (-) Length 114 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID R3JGB1
Locus tag KJA96_RS12950 Protein ID WP_002354773.1
Coordinates 2690748..2690978 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KJA96_RS12940 (2686422) 2686422..2690036 - 3615 WP_002389470.1 DNA-directed RNA polymerase subunit beta -
KJA96_RS12945 (2690407) 2690407..2690748 - 342 WP_002354774.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
KJA96_RS12950 (2690748) 2690748..2690978 - 231 WP_002354773.1 hypothetical protein Antitoxin
KJA96_RS12955 (2691392) 2691392..2691607 - 216 WP_002354768.1 zinc ribbon domain-containing protein -
KJA96_RS12960 (2691746) 2691746..2692738 + 993 WP_002365428.1 biotin--[acetyl-CoA-carboxylase] ligase -
KJA96_RS12965 (2692805) 2692805..2693437 - 633 WP_002358972.1 RloB family protein -
KJA96_RS12970 (2693446) 2693446..2694741 - 1296 WP_010820355.1 ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(7-112)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 13156.40 Da        Isoelectric Point: 9.3984

>T294562 WP_002354774.1 NZ_OD940434:c2690748-2690407 [Enterococcus faecalis]
MNVEKKYIPKKGDIVWIDFDPAAGKEIQKRRPGLVVSRYEFNRKTMFAVICPITSTIKNIPTRYTLPDDIETQGQVVISQ
LKSLDFTERKLSQIEHLPLKDMAKIDQIIEYIF

Download         Length: 342 bp

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8677.67 Da        Isoelectric Point: 4.3313

>AT294562 WP_002354773.1 NZ_OD940434:c2690978-2690748 [Enterococcus faecalis]
MLTTKSRRQGSSVVLTLPTDNGKKPKVDQEYIVMYSDDGTITLVPKIQDPFSEGPEGEYYEKDEWHDLAPEGRELF

Download         Length: 231 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0M2A812

References