294556

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) omega-epsilon-zeta/zeta-epsilon
Location 416017..416599 Replicon chromosome
Accession NZ_OD940434
Organism Enterococcus faecalis isolate BX5936

Toxin (Protein)


Gene name zeta Uniprot ID A0A0M2AE74
Locus tag KJA96_RS02150 Protein ID WP_002355414.1
Coordinates 416291..416599 (+) Length 103 a.a.

Antitoxin (Protein)


Gene name epsilon Uniprot ID Q9AL19
Locus tag KJA96_RS02145 Protein ID WP_002326825.1
Coordinates 416017..416289 (+) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KJA96_RS02115 (411298) 411298..412026 - 729 WP_002355404.1 GntR family transcriptional regulator -
KJA96_RS02120 (412203) 412203..413129 + 927 WP_002355406.1 hypothetical protein -
KJA96_RS02125 (413146) 413146..414429 + 1284 WP_002363033.1 PTS sugar transporter subunit IIC -
KJA96_RS02130 (414621) 414621..414743 + 123 Protein_396 topoisomerase -
KJA96_RS02135 (414818) 414818..415714 + 897 WP_002363034.1 ParA family protein -
KJA96_RS02140 (415791) 415791..416000 + 210 WP_002363035.1 peptide-binding protein -
KJA96_RS02145 (416017) 416017..416289 + 273 WP_002326825.1 antitoxin Antitoxin
KJA96_RS02150 (416291) 416291..416599 + 309 WP_002355414.1 zeta toxin family protein Toxin
KJA96_RS02155 (416679) 416679..417101 - 423 WP_080005963.1 tyrosine-type recombinase/integrase -
KJA96_RS02160 (417152) 417152..417652 - 501 WP_002363039.1 HAD family hydrolase -
KJA96_RS02165 (417657) 417657..418424 - 768 WP_002355416.1 DeoR/GlpR family DNA-binding transcription regulator -
KJA96_RS02170 (418912) 418912..419337 + 426 WP_002355418.1 galactose-6-phosphate isomerase subunit LacA -
KJA96_RS02175 (419354) 419354..419869 + 516 WP_002345825.1 galactose-6-phosphate isomerase subunit LacB -
KJA96_RS02180 (419880) 419880..420812 + 933 WP_002363040.1 tagatose-6-phosphate kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Zeta toxin domain

(27-99)

Antitoxin

Bacterial epsilon antitoxin

(2-90)


Sequences

Toxin        


Download         Length: 103 a.a.        Molecular weight: 11525.91 Da        Isoelectric Point: 5.7251

>T294556 WP_002355414.1 NZ_OD940434:416291-416599 [Enterococcus faecalis]
MANITDFTEKQFEDRLEKNVERLTKNRLAVESPTAFLLGGQPGSGKTSLRSAISEETQGNVVIIDNDTFKQQHPNFDELV
KLYEKDVVKHATSYSNQLVKLN

Download         Length: 309 bp

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 10720.17 Da        Isoelectric Point: 4.4865

>AT294556 WP_002326825.1 NZ_OD940434:416017-416289 [Enterococcus faecalis]
MAVTYEKTFEIEIINELSASVYNRVLNYVLNHELDTKNTRLLEVNLLNQLEVAQEVDLFQQPFEELQAIHEYWRSMNQYS
KQILTKEKVA

Download         Length: 273 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0M2AE74

Antitoxin

Source ID Structure
AlphaFold DB A0A0M2AF93

References