294555

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ImmA-IrrE/HTH_19(antitoxin)
Location 126735..127754 Replicon chromosome
Accession NZ_OD940434
Organism Enterococcus faecalis isolate BX5936

Toxin (Protein)


Gene name IrrE Uniprot ID Q839N5
Locus tag KJA96_RS00550 Protein ID WP_002359283.1
Coordinates 126735..127373 (-) Length 213 a.a.

Antitoxin (Protein)


Gene name ImmA Uniprot ID -
Locus tag KJA96_RS00555 Protein ID WP_002359284.1
Coordinates 127380..127754 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KJA96_RS00525 (122650) 122650..123918 + 1269 WP_002364552.1 RidA family protein -
KJA96_RS00530 (123968) 123968..124411 - 444 WP_002364550.1 MepB family protein -
KJA96_RS00535 (124426) 124426..124971 - 546 WP_002387479.1 ATP:cob(I)alamin adenosyltransferase -
KJA96_RS00540 (125122) 125122..125463 - 342 WP_179115056.1 hypothetical protein -
KJA96_RS00545 (126118) 126118..126693 + 576 WP_002359282.1 restriction endonuclease -
KJA96_RS00550 (126735) 126735..127373 - 639 WP_002359283.1 ImmA/IrrE family metallo-endopeptidase Toxin
KJA96_RS00555 (127380) 127380..127754 - 375 WP_002359284.1 helix-turn-helix domain-containing protein Antitoxin
KJA96_RS00560 (128596) 128596..128778 - 183 WP_002359286.1 hypothetical protein -
KJA96_RS00565 (128945) 128945..129196 + 252 WP_002359287.1 hypothetical protein -
KJA96_RS00570 (129283) 129283..129609 + 327 WP_002359288.1 hypothetical protein -
KJA96_RS00575 (129609) 129609..130016 + 408 WP_002359289.1 DUF961 family protein -
KJA96_RS00580 (130166) 130166..130390 + 225 WP_002359290.1 hypothetical protein -
KJA96_RS00585 (130419) 130419..130610 + 192 WP_010773668.1 hypothetical protein -
KJA96_RS00590 (130592) 130592..130996 + 405 WP_002359292.1 hypothetical protein -
KJA96_RS00595 (131108) 131108..131440 + 333 WP_002359293.1 nucleotidyltransferase domain-containing protein -
KJA96_RS00600 (131430) 131430..131813 + 384 WP_002359294.1 DUF86 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - EF0149 / tufA 120265..197504 77239


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

IrrE N-terminal-like domain

(86-176)

Antitoxin

Cro/C1-type helix-turn-helix domain

(7-61)


Sequences

Toxin        


Download         Length: 213 a.a.        Molecular weight: 25186.21 Da        Isoelectric Point: 9.1676

>T294555 WP_002359283.1 NZ_OD940434:c127373-126735 [Enterococcus faecalis]
MILNKKKLYFETQAFTDKLINEISINMSKRKELINCYDIEAYVKETENIDFFDYPFKKQSKKLIWGSVTKIGDVTMVATA
QHLKIEIKNFTKMHEIIHHYFDYTTDMPNNEKSFDTLLIKKGYLPEDYPKEFRANKGAGMLLINKKALKYAFSTYDDLEK
MASFFNVNDIVLKIRILDELIYSHNLSYKQANLIYNSYYFQQQTQLKEILLK

Download         Length: 639 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14518.29 Da        Isoelectric Point: 4.8896

>AT294555 WP_002359284.1 NZ_OD940434:c127754-127380 [Enterococcus faecalis]
MKTYEKIKQLRENREITQKEISNALDINVSVYNKIELGIRPLREEELTAIADFFNVSIDYLTGRTDNPTTPSNNQKEAGQ
NIISHFRLNTNDLSSDDIEELEKELIDFQEFLIKRAKERKKKSE

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A059N6D0

Antitoxin

Source ID Structure

References