29455

Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 751907..752540 Replicon chromosome
Accession NC_021251
Organism Mycobacterium tuberculosis CCDC5079

Toxin (Protein)


Gene name vapC Uniprot ID G0TQD6
Locus tag CFBS_RS03440 Protein ID WP_003403365.1
Coordinates 751907..752290 (-) Length 128 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ56
Locus tag CFBS_RS03445 Protein ID WP_003403368.1
Coordinates 752385..752540 (-) Length 52 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CFBS_RS03415 747199..747735 + 537 WP_003403341.1 50S ribosomal protein L10 -
CFBS_RS03420 747772..748164 + 393 WP_003403353.1 50S ribosomal protein L7/L12 -
CFBS_RS03425 748157..748852 - 696 WP_003403355.1 TetR/AcrR family transcriptional regulator -
CFBS_RS03430 748923..750428 + 1506 WP_003403360.1 carotenoid cleavage oxygenase -
CFBS_RS03435 750509..751519 + 1011 WP_003911248.1 ABC transporter ATP-binding protein -
CFBS_RS03440 751907..752290 - 384 WP_003403365.1 ribonuclease VapC6 Toxin
CFBS_RS03445 752385..752540 - 156 WP_003403368.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
CFBS_RS03450 752616..753332 - 717 WP_003403371.1 CPBP family intramembrane metalloprotease -
CFBS_RS03455 753608..753916 - 309 WP_003403376.1 type II toxin-antitoxin system PemK/MazF family toxin -
CFBS_RS03460 753903..754148 - 246 WP_003403381.1 ribbon-helix-helix protein, CopG family -
CFBS_RS03465 754258..754695 - 438 WP_003403386.1 type II toxin-antitoxin system VapC family toxin -
CFBS_RS03470 754692..754946 - 255 WP_003911263.1 antitoxin VapB7 -
CFBS_RS03475 755060..757423 + 2364 WP_003901895.1 arylsulfatase AtsD -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

(3-44)


Sequences


Toxin        


Download         Length: 128 a.a.        Molecular weight: 13959.73 Da        Isoelectric Point: 6.0803

>T29455 WP_003403365.1 NC_021251:c752290-751907 [Mycobacterium tuberculosis CCDC5079]
MAAATTTGTHRGLELRAAQRAVGSCEPQRAEFCRSARNADEFDQMSRMFGDVYPDVPVPKSVWRWIDSAQHRLARAGAVG
ALSVVDLLICDTAAARGLVVLHDDADYELAERHLPDIRVRRVVSADD

Download         Length: 384 bp

>T29455 NC_021251:c752290-751907 [Mycobacterium tuberculosis CCDC5079]
TTGGCGGCTGCAACGACAACCGGAACCCACCGAGGCCTGGAACTCCGCGCTGCTCAGCGGGCCGTCGGGTCGTGCGAACC
GCAACGAGCCGAGTTCTGCCGATCAGCGCGGAATGCGGACGAGTTCGACCAGATGAGCCGGATGTTTGGTGACGTCTACC
CCGATGTGCCAGTGCCGAAATCCGTGTGGCGGTGGATCGATTCGGCACAGCACCGCCTCGCCCGGGCGGGAGCGGTGGGT
GCCCTGTCGGTTGTCGATCTGCTGATCTGCGACACTGCGGCGGCCAGGGGCCTAGTAGTCCTCCACGACGATGCCGACTA
CGAACTCGCAGAGCGTCACCTTCCCGACATCAGAGTGCGGAGGGTCGTCAGCGCCGACGACTAG

Antitoxin


Download         Length: 52 a.a.        Molecular weight: 5872.72 Da        Isoelectric Point: 5.7734

>AT29455 WP_003403368.1 NC_021251:c752540-752385 [Mycobacterium tuberculosis CCDC5079]
VSVTQIDLDDEALADVMRIAAVHTKKEAVNLAMRDYVERFRRIEALARSRE

Download         Length: 156 bp

>AT29455 NC_021251:c752540-752385 [Mycobacterium tuberculosis CCDC5079]
GTGTCGGTGACCCAGATCGACCTCGACGACGAAGCGCTGGCCGATGTGATGCGCATCGCCGCCGTGCACACAAAGAAGGA
AGCCGTGAACCTCGCGATGCGCGATTACGTCGAACGGTTTCGGCGCATCGAGGCCCTGGCCCGCTCGCGCGAGTAG

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB G0TQD6


Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BSF8

References