Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907(toxin)
Location 2701270..2701841 Replicon chromosome
Accession NZ_OD940431
Organism Enterococcus faecalis isolate TM6294

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag KJA93_RS12880 Protein ID WP_002396016.1
Coordinates 2701270..2701611 (-) Length 114 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID S4CGQ1
Locus tag KJA93_RS12885 Protein ID WP_002367500.1
Coordinates 2701611..2701841 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KJA93_RS12875 (2697285) 2697285..2700899 - 3615 WP_002389470.1 DNA-directed RNA polymerase subunit beta -
KJA93_RS12880 (2701270) 2701270..2701611 - 342 WP_002396016.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
KJA93_RS12885 (2701611) 2701611..2701841 - 231 WP_002367500.1 hypothetical protein Antitoxin
KJA93_RS12890 (2702254) 2702254..2702469 - 216 WP_213044572.1 zinc ribbon domain-containing protein -
KJA93_RS12895 (2702608) 2702608..2703600 + 993 WP_002358973.1 biotin--[acetyl-CoA-carboxylase] ligase -
KJA93_RS12900 (2703767) 2703767..2704405 - 639 WP_126254829.1 lytic polysaccharide monooxygenase -
KJA93_RS12905 (2705092) 2705092..2706708 + 1617 WP_126254830.1 phosphatase PAP2/LCP family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(10-112)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 13165.46 Da        Isoelectric Point: 9.4141

>T294541 WP_002396016.1 NZ_OD940431:c2701611-2701270 [Enterococcus faecalis]
MNVEKKYIPKKGDIVWIDFDPAAGKEIQQRRLGLVVSRYEFNRKTMFAVICPITSTIKNIPTRYTLPDVIETHGQVVISQ
LKSLDFTERKLSQIEHLPLKDMAKIDQIIEYIF

Download         Length: 342 bp

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8704.69 Da        Isoelectric Point: 4.3313

>AT294541 WP_002367500.1 NZ_OD940431:c2701841-2701611 [Enterococcus faecalis]
MLTTKSRRQGNSVVLTLPTDNGKKPKVDQEYIVMYSDDGTITLVPKIQDPFSEGPEGEYYEKDEWHDLAPEGRELF

Download         Length: 231 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB S4CGQ1

References