Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) omega-epsilon-zeta/zeta-epsilon
Location 1675379..1675961 Replicon chromosome
Accession NZ_OD940422
Organism Enterococcus faecalis isolate WE0851

Toxin (Protein)


Gene name zeta Uniprot ID A0A0M2AE74
Locus tag KJA80_RS07975 Protein ID WP_002355414.1
Coordinates 1675653..1675961 (+) Length 103 a.a.

Antitoxin (Protein)


Gene name epsilon Uniprot ID Q9AL19
Locus tag KJA80_RS07970 Protein ID WP_002326825.1
Coordinates 1675379..1675651 (+) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KJA80_RS07940 (1670660) 1670660..1671388 - 729 WP_002355404.1 GntR family transcriptional regulator -
KJA80_RS07945 (1671565) 1671565..1672491 + 927 WP_002355406.1 hypothetical protein -
KJA80_RS07950 (1672508) 1672508..1673791 + 1284 WP_002363033.1 PTS sugar transporter subunit IIC -
KJA80_RS07955 (1673983) 1673983..1674105 + 123 Protein_1545 topoisomerase -
KJA80_RS07960 (1674180) 1674180..1675076 + 897 WP_002363034.1 ParA family protein -
KJA80_RS07965 (1675153) 1675153..1675362 + 210 WP_002363035.1 peptide-binding protein -
KJA80_RS07970 (1675379) 1675379..1675651 + 273 WP_002326825.1 antitoxin Antitoxin
KJA80_RS07975 (1675653) 1675653..1675961 + 309 WP_002355414.1 zeta toxin family protein Toxin
KJA80_RS07980 (1676041) 1676041..1676463 - 423 WP_080005963.1 tyrosine-type recombinase/integrase -
KJA80_RS07985 (1676514) 1676514..1677014 - 501 WP_002363039.1 HAD family hydrolase -
KJA80_RS07990 (1677019) 1677019..1677786 - 768 WP_002355416.1 DeoR/GlpR family DNA-binding transcription regulator -
KJA80_RS07995 (1678274) 1678274..1678699 + 426 WP_002355418.1 galactose-6-phosphate isomerase subunit LacA -
KJA80_RS08000 (1678716) 1678716..1679231 + 516 WP_002345825.1 galactose-6-phosphate isomerase subunit LacB -
KJA80_RS08005 (1679242) 1679242..1680174 + 933 WP_002363040.1 tagatose-6-phosphate kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1665186..1677014 11828


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Zeta toxin domain

(27-99)

Antitoxin

Bacterial epsilon antitoxin

(2-90)


Sequences

Toxin        


Download         Length: 103 a.a.        Molecular weight: 11525.91 Da        Isoelectric Point: 5.7251

>T294528 WP_002355414.1 NZ_OD940422:1675653-1675961 [Enterococcus faecalis]
MANITDFTEKQFEDRLEKNVERLTKNRLAVESPTAFLLGGQPGSGKTSLRSAISEETQGNVVIIDNDTFKQQHPNFDELV
KLYEKDVVKHATSYSNQLVKLN

Download         Length: 309 bp

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 10720.17 Da        Isoelectric Point: 4.4865

>AT294528 WP_002326825.1 NZ_OD940422:1675379-1675651 [Enterococcus faecalis]
MAVTYEKTFEIEIINELSASVYNRVLNYVLNHELDTKNTRLLEVNLLNQLEVAQEVDLFQQPFEELQAIHEYWRSMNQYS
KQILTKEKVA

Download         Length: 273 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0M2AE74

Antitoxin

Source ID Structure
AlphaFold DB A0A0M2AF93

References