294497

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ImmA-IrrE/Peptidase_M78-HTH_26
Location 1962260..1962958 Replicon chromosome
Accession NZ_OD940420
Organism Enterococcus faecalis isolate WE0438

Toxin (Protein)


Gene name IrrE Uniprot ID A0A828QMF1
Locus tag KJA91_RS09565 Protein ID WP_002388207.1
Coordinates 1962614..1962958 (+) Length 115 a.a.

Antitoxin (Protein)


Gene name ImmA Uniprot ID -
Locus tag KJA91_RS09560 Protein ID WP_002388206.1
Coordinates 1962260..1962595 (+) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KJA91_RS09515 (1957726) 1957726..1958043 - 318 WP_002357007.1 hypothetical protein -
KJA91_RS09520 (1958263) 1958263..1958817 + 555 WP_002357006.1 hypothetical protein -
KJA91_RS09525 (1959102) 1959102..1959440 - 339 WP_002357003.1 hypothetical protein -
KJA91_RS09530 (1959477) 1959477..1959686 - 210 WP_002357002.1 hypothetical protein -
KJA91_RS09535 (1959741) 1959741..1959929 + 189 WP_002357001.1 YegP family protein -
KJA91_RS09540 (1959955) 1959955..1960677 - 723 WP_002357000.1 phage regulatory protein -
KJA91_RS09545 (1960700) 1960700..1961011 - 312 WP_002381719.1 hypothetical protein -
KJA91_RS09550 (1961608) 1961608..1961805 - 198 WP_010712611.1 hypothetical protein -
KJA91_RS09555 (1961818) 1961818..1962000 - 183 WP_002388205.1 hypothetical protein -
KJA91_RS09560 (1962260) 1962260..1962595 + 336 WP_002388206.1 helix-turn-helix transcriptional regulator Antitoxin
KJA91_RS09565 (1962614) 1962614..1962958 + 345 WP_002388207.1 ImmA/IrrE family metallo-endopeptidase Toxin
KJA91_RS09570 (1963016) 1963016..1963744 + 729 WP_002388208.1 potassium channel family protein -
KJA91_RS09575 (1963844) 1963844..1964992 + 1149 WP_002388210.1 site-specific integrase -
KJA91_RS09580 (1965020) 1965020..1965463 - 444 WP_002388212.1 competence type IV pilus minor pilin ComGD -
KJA91_RS09585 (1965460) 1965460..1965735 - 276 WP_002356991.1 competence type IV pilus major pilin ComGC -
KJA91_RS09590 (1965735) 1965735..1966781 - 1047 WP_002377060.1 competence type IV pilus assembly protein ComGB -
KJA91_RS09595 (1966738) 1966738..1967706 - 969 WP_010712613.1 competence type IV pilus ATPase ComGA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

IrrE N-terminal-like domain

(21-86)

Antitoxin

Cro/C1-type helix-turn-helix domain

(5-60)


Sequences

Toxin        


Download         Length: 115 a.a.        Molecular weight: 13625.58 Da        Isoelectric Point: 4.9570

>T294497 WP_002388207.1 NZ_OD940420:1962614-1962958 [Enterococcus faecalis]
MKSIKELVEEYNVELVFTTLNKRACFDPTYGIIFVNQNLTPTEQEEAIYHELKHVEDHVDIMALYKIPVFRSKMESEAEQ
YMFRSLIEKYEGQYNYSNVIAHYNLKMGQEIYLK

Download         Length: 345 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12842.51 Da        Isoelectric Point: 5.2926

>AT294497 WP_002388206.1 NZ_OD940420:1962260-1962595 [Enterococcus faecalis]
MTVFDRIKLLAKERGKSLNRIEEELGLPKNVLYRMKTSDNPTKDRLETLANYFDVSVDYLLGRTDNTKATDEKKSDDLDD
VLDNVMSFDGKPLDDHDREVIRAYLKGRFGK

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A828QMF1

Antitoxin

Source ID Structure

References