Detailed information of TA system TA294487

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/-
• Location: 990205..990658
• Replicon: chromosome
• Accession: NZ_NQJO01000001
• Organism: Erwinia amylovora strain CTBT3-1 tig00000000

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: CS942_RS04650
• Protein ID: WP_013035888.1
• Coordinates: 990422..990658 (+)
• Length: 79 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: D4HZA2
• Locus tag: CS942_RS04645
• Protein ID: WP_004159527.1
• Coordinates: 990205..990432 (+)
• Length: 76 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CS942_RS18790	987330..987590	+	261	WP_013036148.1	hypothetical protein	-
CS942_RS19780	987647..987769	-	123	Protein_864	growth inhibitor PemK	-
CS942_RS04630	987782..989128	+	1347	Protein_865	RHS repeat-associated core domain-containing protein	-
CS942_RS04635	989130..989534	+	405	WP_013035886.1	hypothetical protein	-
CS942_RS04640	989598..989885	-	288	WP_004159528.1	SymE family type I addiction module toxin	-
CS942_RS04645	990205..990432	+	228	WP_004159527.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
CS942_RS04650	990422..990658	+	237	WP_013035888.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
CS942_RS04655	990645..990863	-	219	WP_004159522.1	hypothetical protein	-
CS942_RS04660	991191..993407	+	2217	Protein_871	ferrichrome porin FhuA	-
CS942_RS04665	993456..994250	+	795	WP_004159512.1	Fe3+-hydroxamate ABC transporter ATP-binding protein FhuC	-
CS942_RS04670	994265..995143	+	879	WP_099257966.1	Fe(3+)-hydroxamate ABC transporter substrate-binding protein FhuD	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-78)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-75)

Sequences

Toxin

Protein

• Length: 79 a.a.
• Molecular weight: 9135.79 Da
• Isoelectric Point: 9.0876

>T294487 WP_013035888.1 NZ_NQJO01000001:990422-990658 [Erwinia amylovora]
ISYELLFDPWALKEWKKLGATVREQFKKKLAEVLVNLQVESARLRDHPDCCKIKLKSSGYRLVYQVQDEQLVMLVISV

Nucleotide

• Length: 237 bp

>T294487 NZ_NQJO01000001:990422-990658 [Erwinia amylovora]
ATAAGCTATGAACTGCTCTTCGATCCCTGGGCCTTAAAAGAGTGGAAAAAACTGGGCGCAACGGTTCGGGAACAGTTCAA
AAAGAAACTGGCGGAAGTGCTGGTAAACCTGCAGGTGGAATCAGCCAGGCTGAGAGATCACCCGGACTGCTGCAAAATAA
AGCTGAAATCATCGGGTTATCGTCTGGTATATCAGGTTCAGGATGAACAGCTGGTAATGTTGGTTATAAGCGTTTGA

Antitoxin

Protein

• Length: 76 a.a.
• Molecular weight: 8435.90 Da
• Isoelectric Point: 7.9766

>AT294487 WP_004159527.1 NZ_NQJO01000001:990205-990432 [Erwinia amylovora]
VRLDDKLKSKACAVLDELDVSPTEAVRLLFQYIAENERLPLKALTVSDEKDALLKTVRERLASLQKGIKVTLDKL

Nucleotide

• Length: 228 bp

>AT294487 NZ_NQJO01000001:990205-990432 [Erwinia amylovora]
GTGCGGCTGGACGACAAACTGAAAAGCAAAGCCTGTGCAGTTCTGGATGAACTGGATGTATCGCCAACGGAGGCGGTCCG
GCTGTTGTTCCAGTATATAGCGGAAAATGAGCGCCTACCGCTGAAAGCGCTGACGGTAAGTGATGAAAAAGACGCGCTGC
TGAAAACGGTTCGCGAAAGGCTGGCATCGCTACAGAAGGGAATAAAGGTAACGCTGGATAAGCTATGA

Structures

Antitoxin

• AlphaFold DB: A0A831A410