Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) /HTH_19(antitoxin)
Location 2610153..2610941 Replicon chromosome
Accession NZ_LT996891
Organism Staphylococcus aureus isolate 24117-WT

Toxin (Protein)


Gene name - Uniprot ID A0A2I7Y5B3
Locus tag DYY95_RS13500 Protein ID WP_000525004.1
Coordinates 2610153..2610614 (-) Length 154 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A0E7YIA0
Locus tag DYY95_RS13505 Protein ID WP_000333630.1
Coordinates 2610627..2610941 (-) Length 105 a.a.

Genomic Context


DYY95_RS13480DYY95_RS13510DYY95_RS13515DYY95_RS13520DYY95_RS13530DYY95_RS13540DYY95_RS13545DYY95_RS13550DYY95_RS13555DYY95_RS13560DYY95_RS13565DYY95_RS13475DYY95_RS13485DYY95_RS13490DYY95_RS13495DYY95_RS13500DYY95_RS13505DYY95_RS13525DYY95_RS13535
Location: 2608431..2609045 (615 bp)
Type: Others
Protein ID: WP_000191464.1
Location: 2611093..2611329 (237 bp)
Type: Others
Protein ID: WP_001121027.1
Location: 2611343..2612119 (777 bp)
Type: Others
Protein ID: WP_001148544.1
Location: 2612148..2612291 (144 bp)
Type: Others
Protein ID: WP_000939498.1
Location: 2612546..2612791 (246 bp)
Type: Others
Protein ID: WP_001025401.1
Location: 2613180..2613395 (216 bp)
Type: Others
Protein ID: WP_001097552.1
Location: 2613422..2613685 (264 bp)
Type: Others
Protein ID: WP_001124198.1
Location: 2613698..2613859 (162 bp)
Type: Others
Protein ID: WP_001285948.1
Location: 2613938..2614261 (324 bp)
Type: Others
Protein ID: WP_000174994.1
Location: 2614276..2614638 (363 bp)
Type: Others
Protein ID: WP_000985976.1
Location: 2614635..2615801 (1167 bp)
Type: Others
Protein ID: WP_000762545.1
Location: 2607100..2608305 (1206 bp)
Type: Others
Protein ID: WP_000264751.1
Location: 2609042..2609188 (147 bp)
Type: Others
Protein ID: WP_001795334.1
Location: 2609277..2609672 (396 bp)
Type: Others
Protein ID: WP_000449655.1
Location: 2609701..2610135 (435 bp)
Type: Others
Protein ID: WP_115657847.1
Location: 2610153..2610614 (462 bp)
Type: Toxin
Protein ID: WP_000525004.1
Location: 2610627..2610941 (315 bp)
Type: Antitoxin
Protein ID: WP_000333630.1
Location: 2612281..2612490 (210 bp)
Type: Others
Protein ID: WP_000642492.1
Location: 2612760..2613125 (366 bp)
Type: Others
Protein ID: WP_001128433.1
ToxinAntitoxinOther genes
Loading, please wait
Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
DYY95_RS134752607100..2608305-1206WP_000264751.1site-specific integrase-
DYY95_RS134802608431..2609045+615WP_000191464.1hypothetical protein-
DYY95_RS134852609042..2609188-147WP_001795334.1hypothetical protein-
DYY95_RS134902609277..2609672-396WP_000449655.1hypothetical protein-
DYY95_RS134952609701..2610135-435WP_115657847.1hypothetical protein-
DYY95_RS135002610153..2610614-462WP_000525004.1hypothetical proteinToxin
DYY95_RS135052610627..2610941-315WP_000333630.1helix-turn-helix domain-containing proteinAntitoxin
DYY95_RS135102611093..2611329+237WP_001121027.1helix-turn-helix domain-containing protein-
DYY95_RS135152611343..2612119+777WP_001148544.1Rha family transcriptional regulator-
DYY95_RS135202612148..2612291+144WP_000939498.1hypothetical protein-
DYY95_RS135252612281..2612490-210WP_000642492.1hypothetical protein-
DYY95_RS135302612546..2612791+246WP_001025401.1DUF2829 domain-containing protein-
DYY95_RS135352612760..2613125-366WP_001128433.1hypothetical protein-
DYY95_RS135402613180..2613395+216WP_001097552.1hypothetical protein-
DYY95_RS135452613422..2613685+264WP_001124198.1helix-turn-helix domain-containing protein-
DYY95_RS135502613698..2613859+162WP_001285948.1DUF1270 domain-containing protein-
DYY95_RS135552613938..2614261+324WP_000174994.1hypothetical protein-
DYY95_RS135602614276..2614638+363WP_000985976.1hypothetical protein-
DYY95_RS135652614635..2615801+1167WP_000762545.1DUF2800 domain-containing protein-

Associated MGEs


Loading, please wait
MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideProphage--2604110..265522151111


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

(4-62)


Sequences


Toxin        


Download         Length: 154 a.a.        Molecular weight: 18074.46 Da        Isoelectric Point: 4.6915

>T294476 WP_000525004.1 NZ_LT996891:c2610614-2610153 [Staphylococcus aureus]
MGLYEETLIQHDYIEIREADVLPDNLDGVWLGDLILIKRGLSDREKAGILFEELAHNKLTYGDIADYSKFNNRKFENYAR
RHGFISAVPLREIVEAYNYGVRNLYELSEYLQLSEEYILEAIEQYKKIYGIGTHYGEYSITFEPLRVFKYKEI

Download         Length: 462 bp


Antitoxin


Download         Length: 105 a.a.        Molecular weight: 12063.56 Da        Isoelectric Point: 6.4736

>AT294476 WP_000333630.1 NZ_LT996891:c2610941-2610627 [Staphylococcus aureus]
MCFSKRMKQSREKQGMTLAELGRKIGKTEATVQRYESGNIKNLKNDTIESIATALNVNPAYLMGWVEENDDEVQHRAAHL
EGELTDDEWQRVLDYADYIRSKRK

Download         Length: 315 bp


Similar Proteins


Only experimentally validated proteins are listed.

Loading, please wait
Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
Loading, please wait
Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures


Toxin

Loading, please wait
Source
ID
Structure
AlphaFold DBA0A2I7Y5B3


Antitoxin

Loading, please wait
Source
ID
Structure
AlphaFold DBA0A0E7YIA0

References