Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 2074078..2074607 Replicon chromosome
Accession NZ_LT996889
Organism Staphylococcus aureus isolate 24117-REV

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag DYY93_RS10550 Protein ID WP_000621175.1
Coordinates 2074245..2074607 (+) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID T1YCG8
Locus tag DYY93_RS10545 Protein ID WP_000948331.1
Coordinates 2074078..2074248 (+) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DYY93_RS10515 2069114..2069674 + 561 WP_001092409.1 K(+)-transporting ATPase subunit C -
DYY93_RS10520 2069883..2070362 + 480 WP_001287079.1 hypothetical protein -
DYY93_RS10525 2070355..2071938 + 1584 WP_001294620.1 PH domain-containing protein -
DYY93_RS10530 2071925..2072416 + 492 WP_001205912.1 PH domain-containing protein -
DYY93_RS10535 2072420..2072779 + 360 WP_000581202.1 holo-ACP synthase -
DYY93_RS10540 2072845..2073993 + 1149 WP_000130547.1 alanine racemase -
DYY93_RS10545 2074078..2074248 + 171 WP_000948331.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
DYY93_RS10550 2074245..2074607 + 363 WP_000621175.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
DYY93_RS10560 2074956..2075957 + 1002 WP_000390829.1 PP2C family protein-serine/threonine phosphatase -
DYY93_RS10565 2076076..2076402 + 327 WP_001052491.1 anti-sigma factor antagonist -
DYY93_RS10570 2076404..2076883 + 480 WP_001190829.1 anti-sigma B factor RsbW -
DYY93_RS10575 2076858..2077628 + 771 WP_001041107.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-110)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13441.69 Da        Isoelectric Point: 10.1654

>T294448 WP_000621175.1 NZ_LT996889:2074245-2074607 [Staphylococcus aureus]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTYLSDDKMKEVDNALMISLGLNAVAHQKN

Download         Length: 363 bp

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6251.78 Da        Isoelectric Point: 3.8305

>AT294448 WP_000948331.1 NZ_LT996889:2074078-2074248 [Staphylococcus aureus]
MLSFSQNRSHSLEQSLKEGYSQMADLNLSLANEAFPIECEACDCNETYLSSNSTNE

Download         Length: 171 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VRZ1

References