Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2054335..2054849 Replicon chromosome
Accession NZ_LT996889
Organism Staphylococcus aureus isolate 24117-REV

Toxin (Protein)


Gene name TsdT Uniprot ID T1YA99
Locus tag DYY93_RS10460 Protein ID WP_000581792.1
Coordinates 2054640..2054849 (+) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID W8UW13
Locus tag DYY93_RS10455 Protein ID WP_000138932.1
Coordinates 2054335..2054628 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DYY93_RS10425 2049684..2050325 + 642 WP_000483153.1 thiamine phosphate synthase -
DYY93_RS10430 2050411..2051283 + 873 WP_000725802.1 membrane protein insertase YidC -
DYY93_RS10445 2052010..2052657 - 648 WP_001187634.1 HD domain-containing protein -
DYY93_RS10450 2052685..2054169 - 1485 WP_000571549.1 cardiolipin synthase -
DYY93_RS10455 2054335..2054628 + 294 WP_000138932.1 copper-sensing transcriptional repressor CsoR Antitoxin
DYY93_RS10460 2054640..2054849 + 210 WP_000581792.1 heavy-metal-associated domain-containing protein Toxin
DYY93_RS10465 2054977..2055114 + 138 WP_000828354.1 hypothetical protein -
DYY93_RS10470 2055378..2056580 - 1203 WP_001109939.1 rod shape-determining protein RodA -
DYY93_RS10475 2056898..2057968 + 1071 WP_000159631.1 D-alanine--D-alanine ligase -
DYY93_RS10480 2057983..2059341 + 1359 WP_000611465.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7843.77 Da        Isoelectric Point: 4.1008

>T294447 WP_000581792.1 NZ_LT996889:2054640-2054849 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11197.82 Da        Isoelectric Point: 6.2243

>AT294447 WP_000138932.1 NZ_LT996889:2054335-2054628 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FF1

Antitoxin

Source ID Structure
AlphaFold DB W8UW13

References