Detailed information of TA system TA294433

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafQ-DinJ
• Location: 1401261..1401805
• Replicon: chromosome
• Accession: NZ_LT996885
• Organism: Dialister massiliensis strain Marseille-P5638

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: DHT67_RS06500
• Protein ID: WP_022381609.1
• Coordinates: 1401530..1401805 (+)
• Length: 92 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: DHT67_RS06495
• Protein ID: WP_022381610.1
• Coordinates: 1401261..1401533 (+)
• Length: 91 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DHT67_RS06475	1397445..1398860	+	1416	WP_108850317.1	DNA primase family protein	-
DHT67_RS06480	1399006..1399287	+	282	WP_108850318.1	VRR-NUC domain-containing protein	-
DHT67_RS06485	1399268..1400623	+	1356	WP_108850319.1	DEAD/DEAH box helicase	-
DHT67_RS06490	1400620..1401078	+	459	WP_108850320.1	hypothetical protein	-
DHT67_RS06495	1401261..1401533	+	273	WP_022381610.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
DHT67_RS06500	1401530..1401805	+	276	WP_022381609.1	type II toxin-antitoxin system YafQ family toxin	Toxin
DHT67_RS06505	1402082..1402462	+	381	WP_108850321.1	HNH endonuclease	-
DHT67_RS06510	1402592..1403158	+	567	WP_108850322.1	P27 family phage terminase small subunit	-
DHT67_RS06515	1403161..1404390	+	1230	WP_108850323.1	DNA modification methylase	-
DHT67_RS06520	1404390..1404938	+	549	WP_108850324.1	N-acetylmuramoyl-L-alanine amidase	-
DHT67_RS06525	1404940..1405215	+	276	WP_108850325.1	prevent-host-death protein	-
DHT67_RS06530	1405305..1405994	+	690	WP_108850326.1	virulence protein	-
DHT67_RS06535	1405978..1406205	+	228	WP_074502258.1	DUF4314 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1397640..1421569	23929

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (3-91)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-76)

Sequences

Toxin

Protein

• Length: 92 a.a.
• Molecular weight: 10766.43 Da
• Isoelectric Point: 7.2406

>T294433 WP_022381609.1 NZ_LT996885:1401530-1401805 [Dialister massiliensis]
MKYEVKFTTQFKKDLKLAKKQNKDIDVLFSVIEQLAQGKQLDEKYRDHDLGGTYKGCRECHIDPDWLLIYETKDDVLVLL
LYRLGSHSQLF

Nucleotide

• Length: 276 bp

Antitoxin

Protein

• Length: 91 a.a.
• Molecular weight: 10153.81 Da
• Isoelectric Point: 10.5419

>AT294433 WP_022381610.1 NZ_LT996885:1401261-1401533 [Dialister massiliensis]
MVNTNLNIRTDKEVKNQAEKIFNALGMNMTTAVNIFLKTTIRENGIPFRLTLDVPNATTRSAIEEGKRIAIDKKVKGYTN
MTDLRVALEK

Nucleotide

• Length: 273 bp