Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3868329..3868986 Replicon chromosome
Accession NZ_LT992502
Organism Enterobacter bugandensis isolate EB-247

Toxin (Protein)


Gene name cptA Uniprot ID A0A2J7SFN6
Locus tag DG357_RS18660 Protein ID WP_028014322.1
Coordinates 3868329..3868739 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID V3PWU7
Locus tag DG357_RS18665 Protein ID WP_010435322.1
Coordinates 3868720..3868986 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DG357_RS18640 3864322..3866055 - 1734 WP_041908356.1 single-stranded-DNA-specific exonuclease RecJ -
DG357_RS18645 3866061..3866774 - 714 WP_049136419.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
DG357_RS18650 3866803..3867699 - 897 WP_028014320.1 site-specific tyrosine recombinase XerD -
DG357_RS18655 3867801..3868322 + 522 WP_041908355.1 flavodoxin FldB -
DG357_RS18660 3868329..3868739 - 411 WP_028014322.1 protein YgfX Toxin
DG357_RS18665 3868720..3868986 - 267 WP_010435322.1 FAD assembly factor SdhE Antitoxin
DG357_RS18670 3869281..3870261 + 981 WP_048960833.1 tRNA-modifying protein YgfZ -
DG357_RS18675 3870349..3871008 - 660 WP_023331242.1 hemolysin III family protein -
DG357_RS18680 3871274..3872005 + 732 WP_028014325.1 MurR/RpiR family transcriptional regulator -
DG357_RS18685 3872122..3873555 + 1434 WP_059358111.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16024.98 Da        Isoelectric Point: 11.2845

>T294431 WP_028014322.1 NZ_LT992502:c3868739-3868329 [Enterobacter bugandensis]
VVLWQSDLRVSWRSQWMSLLLHGLVAAIVLLMPWPLSYTPLWLLLLSFVVFDSVRSQRRINARQGEIKLLMDSRLRWQGK
EWDILGVPWMLNAGMMLRLRKVGGGRCQHLWLAADSMDASEWRDLRRMLLQQPTQE

Download         Length: 411 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10555.02 Da        Isoelectric Point: 5.1340

>AT294431 WP_010435322.1 NZ_LT992502:c3868986-3868720 [Enterobacter bugandensis]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDSLSDDDKRLFVRLLESDDPDLFNWLMNHGKPADTELQRMVQLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2J7SFN6

Antitoxin

Source ID Structure
AlphaFold DB V3PWU7

References