Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) kacAT/DUF1778(antitoxin)
Location 1735019..1735816 Replicon chromosome
Accession NZ_LT992502
Organism Enterobacter bugandensis isolate EB-247

Toxin (Protein)


Gene name KacT Uniprot ID -
Locus tag DG357_RS08395 Protein ID WP_172616463.1
Coordinates 1735316..1735816 (+) Length 167 a.a.

Antitoxin (Protein)


Gene name KacA Uniprot ID W7PG43
Locus tag DG357_RS08390 Protein ID WP_008499829.1
Coordinates 1735019..1735288 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DG357_RS08360 1730649..1731092 - 444 WP_028012647.1 helix-turn-helix transcriptional regulator -
DG357_RS08365 1731245..1732486 + 1242 WP_088204980.1 bifunctional glucose-1-phosphatase/inositol phosphatase -
DG357_RS08370 1732520..1732747 - 228 WP_028012649.1 YccJ family protein -
DG357_RS08375 1732766..1733362 - 597 WP_041910554.1 NAD(P)H:quinone oxidoreductase -
DG357_RS08380 1733753..1733923 + 171 WP_001273664.1 general stress protein -
DG357_RS08385 1734040..1734957 + 918 WP_088204981.1 DMT family transporter -
DG357_RS08390 1735019..1735288 + 270 WP_008499829.1 DUF1778 domain-containing protein Antitoxin
DG357_RS08395 1735316..1735816 + 501 WP_172616463.1 N-acetyltransferase Toxin
DG357_RS08400 1735875..1737197 - 1323 WP_048959639.1 pyrimidine utilization transport protein G -
DG357_RS08405 1737219..1737713 - 495 WP_028012654.1 pyrimidine utilization flavin reductase protein F -
DG357_RS08410 1737723..1738313 - 591 WP_041910551.1 malonic semialdehyde reductase -
DG357_RS08415 1738323..1739123 - 801 WP_028012656.1 pyrimidine utilization protein D -
DG357_RS08420 1739131..1739517 - 387 WP_088204983.1 pyrimidine utilization protein C -
DG357_RS08425 1739529..1740218 - 690 WP_028012657.1 pyrimidine utilization protein B -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Vibrio phage ICP1, Orf50

(8-86)


Sequences

Toxin        


Download         Length: 167 a.a.        Molecular weight: 18873.63 Da        Isoelectric Point: 8.4785

>T294426 WP_172616463.1 NZ_LT992502:1735316-1735816 [Enterobacter bugandensis]
MFSEGTDYDFGDFDCGEPSLNAFLREHLVRQHNGRILRAYLLKERDHPRVLGYYTLSGSCFERAMLPSKTQQRRIPYLNV
PSVTLGRLAIHKELQGNEWGTTLVAHAMRVVYLASQAVGVHGIFVDALSEQAKRFYLKLGFIPLAGENSHSLFFPTKAIE
RLFEQA

Download         Length: 501 bp

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10262.72 Da        Isoelectric Point: 5.8836

>AT294426 WP_008499829.1 NZ_LT992502:1735019-1735288 [Enterobacter bugandensis]
MPALKKQRIDLRLTDEDKTMIEEAAAMTNQTITQFMVNSASERAAEVIEQHRRLVLNEASWNAVMDAIDNPPEPNERLKR
AAKRLRNME

Download         Length: 270 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB W7PG43

References