Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /RES-TIGR02293
Location 1602241..1603154 Replicon chromosome
Accession NZ_LT992502
Organism Enterobacter bugandensis isolate EB-247

Toxin (Protein)


Gene name - Uniprot ID -
Locus tag DG357_RS07740 Protein ID WP_088204937.1
Coordinates 1602241..1602714 (-) Length 158 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID -
Locus tag DG357_RS07745 Protein ID WP_045261776.1
Coordinates 1602711..1603154 (-) Length 148 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DG357_RS07720 1598400..1599710 + 1311 WP_088204934.1 type I-F CRISPR-associated protein Csy1 -
DG357_RS07725 1599707..1600642 + 936 WP_088204935.1 type I-F CRISPR-associated protein Csy2 -
DG357_RS07730 1600656..1601654 + 999 WP_045261779.1 type I-F CRISPR-associated protein Csy3 -
DG357_RS07735 1601664..1602218 + 555 WP_088204936.1 type I-F CRISPR-associated endoribonuclease Cas6/Csy4 -
DG357_RS07740 1602241..1602714 - 474 WP_088204937.1 RES domain-containing protein Toxin
DG357_RS07745 1602711..1603154 - 444 WP_045261776.1 DUF2384 domain-containing protein Antitoxin
DG357_RS07750 1603772..1603990 - 219 WP_002211347.1 translation initiation factor IF-1 -
DG357_RS07755 1604275..1604979 - 705 WP_041910636.1 leucyl/phenylalanyl-tRNA--protein transferase -
DG357_RS07760 1605025..1606746 - 1722 WP_088204938.1 cysteine/glutathione ABC transporter ATP-binding protein/permease CydC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(3-147)

Antitoxin

Antitoxin Xre-like, helix-turn-helix domain

(30-90)


Sequences

Toxin        


Download         Length: 158 a.a.        Molecular weight: 17531.88 Da        Isoelectric Point: 5.0700

>T294425 WP_088204937.1 NZ_LT992502:c1602714-1602241 [Enterobacter bugandensis]
MIFYRLVTGRYASEAWSGSGANQYGGRWNHKGHPAVYVSTSISLASLEILVHIRKDTVLNQYQLFSIDIPDDQIDYLDKA
WLPEDWQENPAPVSTMDLGTGWLQASSALALILPSCIIPYENNAILNPLHPAFHTALSSVQQMPFIFDTRLAEKTAP

Download         Length: 474 bp

Antitoxin


Download         Length: 148 a.a.        Molecular weight: 16365.72 Da        Isoelectric Point: 8.5886

>AT294425 WP_045261776.1 NZ_LT992502:c1603154-1602711 [Enterobacter bugandensis]
MRTWIPAKKPADNALWRYAGLPANRGMRLIEFLNQGLPVSVLDNIHEWTAMSKADILRVTGINERNVARRKSAGRTLTPD
ESERVARFVRVLDAAVDYFGSKEEAWNWLQSPVRGLGNVAPVDLIATETGALEVTDLIGRLEHGVFA

Download         Length: 444 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References