294424

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1143769..1144389 Replicon chromosome
Accession NZ_LT992502
Organism Enterobacter bugandensis isolate EB-247

Toxin (Protein)


Gene name Hha Uniprot ID A0A1H8SI38
Locus tag DG357_RS05485 Protein ID WP_008499287.1
Coordinates 1143769..1143987 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A8E1RNX1
Locus tag DG357_RS05490 Protein ID WP_028012188.1
Coordinates 1144015..1144389 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DG357_RS05455 1139780..1140040 + 261 WP_006176933.1 type B 50S ribosomal protein L31 -
DG357_RS05460 1140043..1140183 + 141 WP_003859006.1 type B 50S ribosomal protein L36 -
DG357_RS05465 1140180..1140890 - 711 WP_088205223.1 GNAT family N-acetyltransferase -
DG357_RS05470 1140992..1142452 + 1461 WP_088205222.1 PLP-dependent aminotransferase family protein -
DG357_RS05475 1142424..1142891 - 468 WP_028012186.1 membrane protein -
DG357_RS05480 1143008..1143559 - 552 WP_028012187.1 maltose O-acetyltransferase -
DG357_RS05485 1143769..1143987 - 219 WP_008499287.1 hemolysin expression modulator Hha Toxin
DG357_RS05490 1144015..1144389 - 375 WP_028012188.1 Hha toxicity modulator TomB Antitoxin
DG357_RS05495 1144899..1148045 - 3147 WP_047367620.1 multidrug efflux RND transporter permease subunit AcrB -
DG357_RS05500 1148068..1149261 - 1194 WP_028012190.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-114)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8612.00 Da        Isoelectric Point: 8.9008

>T294424 WP_008499287.1 NZ_LT992502:c1143987-1143769 [Enterobacter bugandensis]
MSDKPLTKIDYLMRLRRCQSIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFVR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14511.30 Da        Isoelectric Point: 4.8886

>AT294424 WP_028012188.1 NZ_LT992502:c1144389-1144015 [Enterobacter bugandensis]
MDEYSPKRHDIAQLKFLCESLYHDCLANLDESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNVSRANPVSLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1H8SI38

Antitoxin

Source ID Structure

References