294393

Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 845977..846505 Replicon chromosome
Accession NZ_LT992491
Organism Vibrio cholerae strain 4295STDY6534200

Toxin (Protein)


Gene name relE Uniprot ID H9L4R3
Locus tag HUW69_RS17495 Protein ID WP_000221352.1
Coordinates 846215..846505 (+) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag HUW69_RS17490 Protein ID WP_002029763.1
Coordinates 845977..846225 (+) Length 83 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HUW69_RS17435 841376..841558 - 183 WP_084998671.1 DUF645 family protein -
HUW69_RS17440 841927..842169 + 243 WP_001107720.1 type II toxin-antitoxin system ParD family antitoxin -
HUW69_RS17445 842166..842465 + 300 WP_000802134.1 type II toxin-antitoxin system RelE/ParE family toxin -
HUW69_RS19165 842642..842734 - 93 Protein_738 DUF645 family protein -
HUW69_RS19170 842701..842823 - 123 Protein_739 DUF645 family protein -
HUW69_RS17455 843180..843351 - 172 Protein_740 DUF645 family protein -
HUW69_RS17460 843664..843951 - 288 WP_000221354.1 type II toxin-antitoxin system RelE/ParE family toxin -
HUW69_RS17465 843941..844192 - 252 WP_001250180.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
HUW69_RS17470 844396..844815 - 420 WP_029628772.1 hypothetical protein -
HUW69_RS17475 844833..844922 - 90 WP_148528902.1 hypothetical protein -
HUW69_RS17480 844991..845359 - 369 WP_029628726.1 hypothetical protein -
HUW69_RS17485 845370..845669 - 300 WP_029628725.1 hypothetical protein -
HUW69_RS17490 845977..846225 + 249 WP_002029763.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
HUW69_RS17495 846215..846505 + 291 WP_000221352.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HUW69_RS17500 846648..847187 - 540 WP_029628805.1 hydrolase -
HUW69_RS17505 847348..847773 - 426 WP_029628792.1 hypothetical protein -
HUW69_RS17510 848008..848526 - 519 WP_029628793.1 hypothetical protein -
HUW69_RS17515 848701..849240 - 540 WP_029628791.1 hydrolase -
HUW69_RS17520 849549..849776 - 228 WP_001894457.1 DUF1289 domain-containing protein -
HUW69_RS17525 850091..850288 - 198 WP_080006741.1 DUF3709 domain-containing protein -
HUW69_RS19175 850282..850443 - 162 Protein_755 hypothetical protein -
HUW69_RS17535 850552..850854 - 303 WP_000818171.1 type II toxin-antitoxin system RelE/ParE family toxin -
HUW69_RS17540 850842..851099 - 258 WP_000861987.1 type II toxin-antitoxin system Phd/YefM family antitoxin -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 806749..965214 158465
- inside Integron - - 806749..961958 155209


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(4-86)

Antitoxin


No domain identified.



Sequences


Toxin        


Download         Length: 97 a.a.        Molecular weight: 11247.23 Da        Isoelectric Point: 10.4678

>T294393 WP_000221352.1 NZ_LT992491:846215-846505 [Vibrio cholerae]
MTYKLEFKKSALKEWKKLAVPLQQQFKKKLIERLENPHVPSAKLSGAENIYKIKLRQSGYRLVYQVENDIIVVTVLAVGK
RERSEVYTKALQRLDD

Download         Length: 291 bp


Antitoxin


Download         Length: 83 a.a.        Molecular weight: 8936.34 Da        Isoelectric Point: 4.3308

>AT294393 WP_002029763.1 NZ_LT992491:845977-846225 [Vibrio cholerae]
MTTRILADVAASITEFKANPMKVATSAFGAPVAVLNRNEPAFYCVPASTYEIMMDKLEDLELLAIAKKRLSEDSVSVNID
DL

Download         Length: 249 bp


Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB H9L4R3


Antitoxin

Source ID Structure

References