Detailed information of TA system TA029439

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 2484400..2485019
• Replicon: chromosome
• Accession: NC_021237
• Organism: Pseudomonas protegens CHA0

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: PFLCHA0_RS11235
• Protein ID: WP_041752740.1
• Coordinates: 2484837..2485019 (-)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: A0A2C9EK34
• Locus tag: PFLCHA0_RS11230
• Protein ID: WP_015634980.1
• Coordinates: 2484400..2484801 (-)
• Length: 134 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
PFLCHA0_RS11200	2479865..2480212	-	348	WP_015634975.1	metalloregulator ArsR/SmtB family transcription factor	-
PFLCHA0_RS11205	2480442..2480996	+	555	WP_041752110.1	hypothetical protein	-
PFLCHA0_RS11210	2481230..2481661	-	432	WP_011060488.1	carboxymuconolactone decarboxylase family protein	-
PFLCHA0_RS11215	2481690..2482310	-	621	WP_015634977.1	NAD(P)H-dependent oxidoreductase	-
PFLCHA0_RS11220	2482307..2482753	-	447	WP_041752112.1	GNAT family N-acetyltransferase	-
PFLCHA0_RS11225	2482841..2484244	+	1404	WP_015634979.1	PLP-dependent aminotransferase family protein	-
PFLCHA0_RS11230	2484400..2484801	-	402	WP_015634980.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
PFLCHA0_RS11235	2484837..2485019	-	183	WP_041752740.1	type II toxin-antitoxin system HicA family toxin	Toxin
PFLCHA0_RS31155	2485712..2486230	+	519	WP_053150430.1	sugar O-acetyltransferase	-
PFLCHA0_RS11240	2486251..2487489	+	1239	WP_015634984.1	aspartate aminotransferase family protein	-
PFLCHA0_RS11245	2487542..2489254	+	1713	WP_041752741.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (3-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-127)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6959.13 Da
• Isoelectric Point: 10.9595

>T29439 WP_041752740.1 NC_021237:c2485019-2484837 [Pseudomonas protegens CHA0]
VQSRQLIKELEATGWVLERVTESHHLFKHPYRPNTVPAPHPKKDLPRGTVRAIRKLAELI

Nucleotide

• Length: 183 bp

>T29439 NC_021237:c2485019-2484837 [Pseudomonas protegens CHA0]
GTGCAAAGCAGACAGTTGATCAAGGAGCTTGAAGCCACAGGATGGGTGCTGGAGCGAGTCACCGAAAGCCATCATCTGTT
CAAGCATCCTTACAGGCCCAACACCGTTCCGGCGCCTCACCCGAAGAAGGATCTGCCACGGGGTACGGTCAGGGCCATCA
GAAAACTGGCTGAACTGATCTAG

Antitoxin

Protein

• Length: 134 a.a.
• Molecular weight: 14582.57 Da
• Isoelectric Point: 5.1666

>AT29439 WP_015634980.1 NC_021237:c2484801-2484400 [Pseudomonas protegens CHA0]
VQYPICIEWGDEHTATGIQIPDIPGAVTAGDSFESAYSAAIEIAHVMLEELARAGHAIPLPSPTRKHRANPDFEGMGWGM
LDIDIAPYLGKTEKVNVTLPGYVIQQIDRFVREHNIKSRSSFLADAALEKLGR

Nucleotide

• Length: 402 bp

>AT29439 NC_021237:c2484801-2484400 [Pseudomonas protegens CHA0]
GTGCAATATCCCATCTGCATCGAATGGGGCGACGAACACACCGCCACCGGCATCCAGATTCCTGATATTCCCGGCGCAGT
CACCGCCGGCGACAGCTTCGAGAGCGCCTACAGCGCGGCCATCGAGATTGCCCACGTCATGCTCGAAGAGCTGGCCCGAG
CGGGGCACGCCATTCCCCTGCCCTCTCCCACCCGCAAGCACCGCGCCAACCCCGATTTCGAGGGCATGGGCTGGGGCATG
CTGGATATCGATATCGCGCCTTATCTGGGCAAGACCGAGAAGGTCAACGTGACCCTGCCGGGTTATGTCATCCAGCAAAT
CGACCGCTTTGTCCGCGAGCACAACATCAAGAGCCGGTCGTCTTTCCTGGCCGATGCCGCGCTGGAAAAGCTCGGGCGCT
GA

Structures

Antitoxin

• AlphaFold DB: A0A2C9EK34