Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ataRT/DUF1778(antitoxin)
Location 2416631..2417394 Replicon chromosome
Accession NZ_LT992490
Organism Vibrio cholerae strain 4295STDY6534200

Toxin (Protein)


Gene name ataT Uniprot ID A0A501Y1C9
Locus tag HUW69_RS10775 Protein ID WP_029627974.1
Coordinates 2416888..2417394 (+) Length 169 a.a.

Antitoxin (Protein)


Gene name ataR Uniprot ID A0A501XZ00
Locus tag HUW69_RS10770 Protein ID WP_032481064.1
Coordinates 2416631..2416897 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HUW69_RS10755 2413519..2414211 - 693 WP_024008832.1 DsbC family protein -
HUW69_RS10760 2414553..2415491 + 939 WP_029627976.1 Abi family protein -
HUW69_RS10765 2415917..2416453 + 537 WP_029627975.1 hypothetical protein -
HUW69_RS10770 2416631..2416897 + 267 WP_032481064.1 DUF1778 domain-containing protein Antitoxin
HUW69_RS10775 2416888..2417394 + 507 WP_029627974.1 GNAT family N-acetyltransferase Toxin
HUW69_RS10780 2417435..2417821 - 387 WP_029627973.1 hypothetical protein -
HUW69_RS10785 2417818..2418390 - 573 WP_001944091.1 type IV conjugative transfer system lipoprotein TraV -
HUW69_RS10790 2418465..2419754 - 1290 WP_029627971.1 TraB/VirB10 family protein -
HUW69_RS10795 2419757..2420653 - 897 WP_032471966.1 type-F conjugative transfer system secretin TraK -
HUW69_RS10800 2420637..2421263 - 627 WP_029627969.1 pilus assembly protein -
HUW69_RS10805 2421260..2421541 - 282 WP_000433889.1 type IV conjugative transfer system protein TraL -
HUW69_RS10810 2421774..2422070 + 297 WP_054104212.1 HigA family addiction module antidote protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 2315752..2450139 134387


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(42-146)

Antitoxin

Vibrio phage ICP1, Orf50

(8-83)


Sequences

Toxin        


Download         Length: 169 a.a.        Molecular weight: 18320.04 Da        Isoelectric Point: 6.7043

>T294386 WP_029627974.1 NZ_LT992490:2416888-2417394 [Vibrio cholerae]
MGISAPTLLADEHQINAFQCGIEELDTWLRKQALKSQKRGTARVYVVNDTDAHQVVGYYAIAMGSVSREQAFSSLRRNSP
DPIPMVILARLGVDNAYQGQGIAAGLLKDCIIRSVQAMNAVGGAGILVHAIDDTAQTFYKKFGFKESTFDPLVLMARICD
IEKSLSID

Download         Length: 507 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9941.46 Da        Isoelectric Point: 7.0146

>AT294386 WP_032481064.1 NZ_LT992490:2416631-2416897 [Vibrio cholerae]
MATKTAPINMRVLPSVRDIIDAAASLKKVDRTVFIQQAALNEAHSILAEQRDFVLEAKAFEAFDNELRANPQTLEGMKDL
FKRKAPWE

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A501Y1C9

Antitoxin

Source ID Structure
AlphaFold DB A0A501XZ00

References