Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/upstrm_HI1419-dnstrm_HI1420
Location 762666..763262 Replicon chromosome
Accession NC_021237
Organism Pseudomonas protegens CHA0

Toxin (Protein)


Gene name relE Uniprot ID A0A2C9EFT8
Locus tag PFLCHA0_RS03295 Protein ID WP_015633982.1
Coordinates 762960..763262 (-) Length 101 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A2C9EFR9
Locus tag PFLCHA0_RS03290 Protein ID WP_015633981.1
Coordinates 762666..762956 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PFLCHA0_RS03270 758936..761068 - 2133 WP_015633979.1 TonB-dependent copper receptor -
PFLCHA0_RS03275 761157..761567 - 411 WP_041115676.1 DUF2946 domain-containing protein -
PFLCHA0_RS03280 761623..762102 - 480 WP_026020078.1 copper chaperone PCu(A)C -
PFLCHA0_RS03285 762167..762565 - 399 WP_011059019.1 DUF2946 domain-containing protein -
PFLCHA0_RS03290 762666..762956 - 291 WP_015633981.1 putative addiction module antidote protein Antitoxin
PFLCHA0_RS03295 762960..763262 - 303 WP_015633982.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PFLCHA0_RS03300 763446..764174 - 729 WP_011059022.1 cobalt-precorrin-6A reductase -
PFLCHA0_RS03305 764171..765268 - 1098 WP_015633983.1 cobalt-precorrin-5B (C(1))-methyltransferase -
PFLCHA0_RS03310 765362..766576 - 1215 WP_011059024.1 bifunctional cobalt-precorrin-7 (C(5))-methyltransferase/cobalt-precorrin-6B (C(15))-methyltransferase -
PFLCHA0_RS03315 766715..768028 + 1314 WP_015633984.1 precorrin-3B synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(4-95)

Antitoxin

Uncharacterized protein HI1420

(3-94)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11504.34 Da        Isoelectric Point: 10.6512

>T29438 WP_015633982.1 NC_021237:c763262-762960 [Pseudomonas protegens CHA0]
MFVFEQTPEFSRWLLNLKDPQGKTRVLARIRAAQLGRFGDCEPVGEGVHEMRIHRGPGYRVYFSRRGKVIYLLLIGGDKA
TQKRDIQRARQLACDLKSEG

Download         Length: 303 bp

>T29438 NC_021237:c763262-762960 [Pseudomonas protegens CHA0]
ATGTTCGTTTTCGAGCAGACTCCTGAGTTCAGCCGCTGGCTGCTGAACCTGAAGGACCCGCAAGGGAAAACCCGTGTACT
GGCCAGGATCCGCGCCGCACAGCTGGGCCGTTTTGGCGACTGCGAACCTGTGGGCGAAGGCGTCCACGAGATGCGCATCC
ACCGCGGTCCGGGTTACCGGGTGTACTTCTCGCGCCGCGGCAAAGTGATCTACCTGCTGTTGATCGGCGGCGACAAGGCC
ACCCAGAAACGCGATATCCAACGGGCCAGGCAACTGGCCTGCGACCTCAAGAGCGAGGGCTGA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10422.96 Da        Isoelectric Point: 6.2901

>AT29438 WP_015633981.1 NC_021237:c762956-762666 [Pseudomonas protegens CHA0]
MRTPVTRFDAAEYLKTPEDMVAYLNACFEEDTGDGVLIRAALNDIARARGMTQVARDTGLGRESLYKALGSQGNPEFATI
IKVMKALGLKINVSNA

Download         Length: 291 bp

>AT29438 NC_021237:c762956-762666 [Pseudomonas protegens CHA0]
ATGCGCACCCCAGTGACCCGCTTCGACGCGGCGGAGTACCTCAAGACCCCTGAAGACATGGTCGCCTACCTCAACGCCTG
CTTCGAGGAAGACACCGGCGACGGCGTGCTGATCCGCGCCGCACTCAACGACATCGCCCGTGCCCGCGGCATGACCCAGG
TCGCCCGTGACACCGGCCTGGGCCGCGAAAGCCTGTACAAGGCCCTCGGCAGCCAGGGCAACCCGGAGTTCGCGACTATC
ATCAAGGTGATGAAGGCCCTGGGGTTGAAGATCAACGTCAGCAACGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2C9EFT8

Antitoxin

Source ID Structure
AlphaFold DB A0A2C9EFR9

References