Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ(toxin)
Location 1044820..1045450 Replicon chromosome
Accession NC_021218
Organism Helicobacter pylori UM066

Toxin (Protein)


Gene name relE Uniprot ID R4QAN1
Locus tag K751_RS04970 Protein ID WP_015642645.1
Coordinates 1044820..1045092 (-) Length 91 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4QML9
Locus tag K751_RS04975 Protein ID WP_015642644.1
Coordinates 1045073..1045450 (-) Length 126 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K751_RS04945 1040280..1041394 - 1115 Protein_961 glycosyltransferase family 8 protein -
K751_RS04950 1041471..1042238 - 768 WP_000242366.1 ABC transporter ATP-binding protein -
K751_RS04955 1042238..1043218 - 981 WP_000921452.1 iron ABC transporter permease -
K751_RS04960 1043211..1044053 - 843 WP_015642646.1 SDR family oxidoreductase -
K751_RS04965 1044194..1044718 + 525 WP_021299711.1 acyl-CoA thioesterase -
K751_RS04970 1044820..1045092 - 273 WP_015642645.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
K751_RS04975 1045073..1045450 - 378 WP_015642644.1 hypothetical protein Antitoxin
K751_RS04980 1046692..1048917 - 2226 WP_015642643.1 Hop family adhesin BabA -
K751_RS05000 1049315..1049929 + 615 WP_015642642.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-90)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 91 a.a.        Molecular weight: 10543.34 Da        Isoelectric Point: 7.2769

>T29436 WP_015642645.1 NC_021218:c1045092-1044820 [Helicobacter pylori UM066]
VLKLNLKKSFQKDFDKLLLNGFDDSVLNEVILTLRKEEPLDPQFKDHALKGNWKPFRECHIKADVLLVYFYLVKGDELIL
VRLGSHSELF

Download         Length: 273 bp

>T29436 NC_021218:c1045092-1044820 [Helicobacter pylori UM066]
GTGTTGAAACTCAACCTTAAAAAATCTTTTCAAAAAGATTTTGATAAATTACTTTTGAATGGGTTTGATGATAGCGTTTT
GAATGAAGTCATTCTAACCTTAAGAAAGGAAGAACCACTAGACCCACAATTTAAAGATCATGCTTTAAAAGGCAATTGGA
AACCTTTTAGAGAATGCCACATCAAAGCTGATGTTTTACTTGTTTATTTTTATTTGGTGAAAGGTGATGAGCTTATTTTA
GTAAGACTAGGCAGTCATAGCGAGCTGTTTTAA

Antitoxin


Download         Length: 126 a.a.        Molecular weight: 14648.61 Da        Isoelectric Point: 8.4602

>AT29436 WP_015642644.1 NC_021218:c1045450-1045073 [Helicobacter pylori UM066]
MPNSPTKKDYTQYSEKQLFNLINQLEQKIKKMQNDRASFKEKMAKGLEKRDQNFKDKIDALNELLQKISQAFDDKRDCCL
GRKIPNLETQQAMRDALNKETDLIVEDFSSYSDERKRALGVETQP

Download         Length: 378 bp

>AT29436 NC_021218:c1045450-1045073 [Helicobacter pylori UM066]
ATGCCTAACTCTCCCACCAAAAAAGATTACACCCAATACAGCGAAAAACAGCTTTTTAACTTAATCAACCAATTAGAGCA
AAAGATCAAAAAGATGCAAAATGATAGAGCTTCTTTTAAAGAAAAAATGGCTAAAGGATTGGAAAAAAGGGATCAAAACT
TTAAGGATAAAATAGATGCATTAAATGAACTCTTGCAAAAAATCAGCCAAGCTTTTGATGATAAAAGAGATTGTTGTTTG
GGGCGCAAGATCCCAAACCTTGAAACGCAACAAGCCATGAGAGATGCGCTTAACAAAGAAACCGATTTGATTGTTGAGGA
TTTTTCTAGTTATAGCGATGAAAGAAAAAGGGCGTTAGGTGTTGAAACTCAACCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB R4QAN1

Antitoxin

Source ID Structure
AlphaFold DB R4QML9

References