Detailed information of TA system TA029434

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): PanAT/DUF4065(antitoxin)
• Location: 1385193..1386393
• Replicon: chromosome
• Accession: NC_021217
• Organism: Helicobacter pylori UM037

Toxin (Protein)

• Gene name: panT
• Uniprot ID: R4QEX8
• Locus tag: K750_RS06720
• Protein ID: WP_015643638.1
• Coordinates: 1385620..1386393 (+)
• Length: 258 a.a.

Antitoxin (Protein)

• Gene name: panA
• Uniprot ID: R4QI14
• Locus tag: K750_RS06715
• Protein ID: WP_015643639.1
• Coordinates: 1385193..1385630 (+)
• Length: 146 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
K750_RS06700	1380337..1383858	+	3522	WP_015643641.1	class I SAM-dependent DNA methyltransferase	-
K750_RS06705	1383859..1384398	+	540	WP_015643640.1	hypothetical protein	-
K750_RS06715	1385193..1385630	+	438	WP_015643639.1	SocA family protein	Antitoxin
K750_RS06720	1385620..1386393	+	774	WP_015643638.1	hypothetical protein	Toxin
K750_RS06725	1386624..1387811	-	1188	WP_015643636.1	transcription termination/antitermination protein NusA	-
K750_RS06730	1387907..1389079	-	1173	WP_015643635.1	L-seryl-tRNA(Sec) selenium transferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Antitoxin SocA-like, Panacea domain (24-119)

Sequences

Toxin

Protein

• Length: 258 a.a.
• Molecular weight: 30160.19 Da
• Isoelectric Point: 8.3838

>T29434 WP_015643638.1 NC_021217:1385620-1386393 [Helicobacter pylori UM037]
METKEEDKDKKLEEIIVSLCEKGDLSSQTDQIIKDLKEIYQGEYRHKYSKITTIILNSTRDREQAFMTLTQNIRTLKEIQ
DNKEVESIKPKLEKLYDHMNLECIRLQDFDEKMSRVKDVSIKLEDDLNKNYKKLSEELNKQQTQYITILGIFASIVLTFV
GGLAFSTSVLSNIDKANAYRLVFVMAFMALFFGNILYLLFSFLSKISLSKEEKDKQENFFKKPKKPIFWFNLMVTILFVI
GFVGELHIIQRLVSKYL

Nucleotide

• Length: 774 bp

>T29434 NC_021217:1385620-1386393 [Helicobacter pylori UM037]
ATGGAAACTAAAGAAGAAGATAAAGATAAAAAGCTAGAAGAAATTATTGTATCGCTGTGTGAAAAGGGGGATTTGTCTAG
CCAAACAGATCAAATCATCAAAGATCTCAAAGAAATCTATCAAGGAGAATACAGGCATAAATACTCAAAAATTACAACTA
TTATTTTAAATTCCACAAGGGATAGAGAGCAAGCCTTTATGACGCTCACACAAAATATAAGGACACTCAAAGAGATTCAA
GATAATAAAGAAGTTGAAAGCATTAAACCAAAACTAGAAAAGCTTTATGATCACATGAATTTAGAGTGTATCAGACTGCA
AGATTTTGATGAGAAAATGAGTAGAGTTAAAGATGTTTCTATCAAGTTAGAAGATGATCTAAATAAAAACTATAAAAAAT
TAAGCGAAGAATTGAATAAGCAACAAACGCAATACATAACAATTTTAGGTATTTTTGCCTCTATTGTTTTAACATTTGTT
GGGGGATTGGCGTTTTCCACTTCTGTTTTATCAAATATTGACAAAGCGAACGCCTACCGTTTGGTTTTTGTTATGGCTTT
TATGGCTTTATTTTTTGGGAATATTTTGTATCTGCTTTTTTCTTTTTTATCAAAAATATCCTTATCAAAAGAGGAAAAAG
ATAAACAAGAAAATTTTTTCAAAAAACCTAAAAAACCTATTTTTTGGTTTAATCTGATGGTTACAATTCTATTTGTGATT
GGTTTTGTGGGAGAATTGCATATAATACAAAGATTAGTTTCTAAATATCTTTAA

Antitoxin

Protein

• Length: 146 a.a.
• Molecular weight: 17253.40 Da
• Isoelectric Point: 6.9813

>AT29434 WP_015643639.1 NC_021217:1385193-1385630 [Helicobacter pylori UM037]
MVNTLELAKYILKHSDKELSNLELQKTLYFTELDYIKKFDKHLVSDDFEAWKYGPVAREVYYEYRNYGANSIDKPKEETL
SQNLRKDELETINHSIEKCSKKSYWDLVKESHKEDGAWHKSFKEDRKEIISKGLIRQEAKQTNGN

Nucleotide

• Length: 438 bp

>AT29434 NC_021217:1385193-1385630 [Helicobacter pylori UM037]
ATGGTCAATACTTTGGAACTAGCAAAATATATTCTTAAGCATTCAGACAAAGAATTGAGTAACTTAGAATTGCAAAAAAC
TTTGTATTTCACAGAGCTTGACTATATCAAAAAGTTTGACAAACACCTAGTTTCTGATGATTTTGAAGCTTGGAAATACG
GGCCTGTTGCAAGGGAAGTGTATTATGAATACCGCAATTATGGTGCCAATTCCATTGACAAACCCAAAGAAGAAACGCTC
TCACAAAATCTTAGAAAAGATGAACTTGAAACCATCAACCACTCCATAGAAAAATGCAGCAAAAAATCCTATTGGGATTT
AGTGAAAGAGAGTCATAAAGAAGATGGCGCTTGGCATAAAAGCTTCAAAGAAGATAGAAAAGAAATCATTAGTAAAGGTT
TGATCAGACAAGAAGCCAAACAAACAAATGGAAACTAA

Structures

Toxin

• AlphaFold DB: R4QEX8

Antitoxin

• AlphaFold DB: R4QI14