Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2369562..2370076 Replicon chromosome
Accession NZ_LT992477
Organism Staphylococcus aureus isolate 22_LA_562

Toxin (Protein)


Gene name TsdT Uniprot ID T1YA99
Locus tag DXE38_RS12020 Protein ID WP_000581792.1
Coordinates 2369867..2370076 (+) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID W8UW13
Locus tag DXE38_RS12015 Protein ID WP_000138932.1
Coordinates 2369562..2369855 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DXE38_RS11995 2365325..2366640 + 1316 Protein_2241 ISL3 family transposase -
DXE38_RS12000 2366637..2366957 - 321 WP_001825748.1 hypothetical protein -
DXE38_RS12005 2367237..2367884 - 648 WP_001187614.1 HD domain-containing protein -
DXE38_RS12010 2367912..2369396 - 1485 WP_000571550.1 cardiolipin synthase -
DXE38_RS12015 2369562..2369855 + 294 WP_000138932.1 copper-sensing transcriptional repressor CsoR Antitoxin
DXE38_RS12020 2369867..2370076 + 210 WP_000581792.1 heavy-metal-associated domain-containing protein Toxin
DXE38_RS12025 2370204..2370341 + 138 WP_000828354.1 hypothetical protein -
DXE38_RS12030 2370605..2371807 - 1203 WP_001109939.1 rod shape-determining protein RodA -
DXE38_RS12035 2372125..2373195 + 1071 WP_000159641.1 D-alanine--D-alanine ligase -
DXE38_RS12040 2373210..2374565 + 1356 WP_000611457.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7843.77 Da        Isoelectric Point: 4.1008

>T294339 WP_000581792.1 NZ_LT992477:2369867-2370076 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11197.82 Da        Isoelectric Point: 6.2243

>AT294339 WP_000138932.1 NZ_LT992477:2369562-2369855 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FF1

Antitoxin

Source ID Structure
AlphaFold DB W8UW13

References