Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ(toxin)
Location 980804..981428 Replicon chromosome
Accession NC_021217
Organism Helicobacter pylori UM037

Toxin (Protein)


Gene name relE Uniprot ID A0A0L0PG12
Locus tag K750_RS04675 Protein ID WP_015643942.1
Coordinates 981150..981428 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Q661
Locus tag K750_RS04670 Protein ID WP_015643943.1
Coordinates 980804..981163 (+) Length 120 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K750_RS04660 976793..977548 + 756 WP_015643945.1 HugZ family heme oxygenase -
K750_RS04665 977805..980036 + 2232 WP_015643944.1 outer membrane beta-barrel protein -
K750_RS04670 980804..981163 + 360 WP_015643943.1 hypothetical protein Antitoxin
K750_RS04675 981150..981428 + 279 WP_015643942.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
K750_RS08720 981558..981701 - 144 WP_015643941.1 hypothetical protein -
K750_RS04680 981821..982966 + 1146 WP_015643940.1 YbfB/YjiJ family MFS transporter -
K750_RS04685 983151..984116 - 966 WP_015643939.1 GTP-binding protein -
K750_RS04690 984116..984493 - 378 WP_015643938.1 hypothetical protein -
K750_RS04695 984539..985420 - 882 WP_015643937.1 polysaccharide deacetylase -
K750_RS04700 985433..986311 - 879 WP_015643936.1 carbon-nitrogen hydrolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(3-82)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10871.07 Da        Isoelectric Point: 9.9131

>T29433 WP_015643942.1 NC_021217:981150-981428 [Helicobacter pylori UM037]
MLKIKHHILYKKDFKKLVKNGFDDSILNEVILTLRKKEPLPPQFKDHALRGVWKPYRECHIKADVLLVYLVKDDELILLR
LAVIASCFINYP

Download         Length: 279 bp

>T29433 NC_021217:981150-981428 [Helicobacter pylori UM037]
ATGCTGAAAATTAAGCACCATATCCTTTACAAAAAAGATTTTAAAAAGCTTGTTAAAAACGGGTTTGATGATAGCATTTT
GAATGAAGTCATTCTAACCTTAAGAAAAAAAGAACCGCTACCCCCACAATTCAAAGATCACGCTTTAAGGGGAGTTTGGA
AGCCTTATAGAGAATGCCATATCAAAGCTGATGTTTTGCTTGTGTATTTAGTGAAAGATGATGAGCTTATTTTGTTAAGA
CTAGCAGTCATAGCGAGTTGTTTTATAAACTACCCATAA

Antitoxin


Download         Length: 120 a.a.        Molecular weight: 14155.94 Da        Isoelectric Point: 6.7207

>AT29433 WP_015643943.1 NC_021217:980804-981163 [Helicobacter pylori UM037]
MPNTTNKDYTKYSQRQLFNLINKKEQEIEKLKRDRAYLEKKMAKELEKKDKGFHNKLEELNKILQEINKRANDCCFGHET
PNIETQQAMREALNGENLETIEDFHAWANEVKKEVNAEN

Download         Length: 360 bp

>AT29433 NC_021217:980804-981163 [Helicobacter pylori UM037]
ATGCCAAACACCACCAACAAAGATTACACAAAATACAGCCAAAGACAGCTTTTTAATCTCATTAATAAAAAAGAACAAGA
AATTGAAAAGCTAAAAAGGGATAGGGCGTATCTTGAAAAGAAAATGGCTAAAGAGCTAGAAAAAAAAGATAAAGGTTTTC
ATAACAAATTAGAAGAGTTGAACAAAATCTTACAAGAGATCAACAAAAGAGCTAATGATTGTTGTTTTGGGCATGAAACC
CCAAATATTGAAACGCAACAAGCCATGAGAGAAGCGTTAAATGGTGAAAACTTAGAAACTATTGAAGACTTTCACGCATG
GGCAAATGAAGTGAAAAAGGAAGTGAATGCTGAAAATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0L0PG12

Antitoxin

Source ID Structure
AlphaFold DB R4Q661

References