Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 1112775..1113551 Replicon chromosome
Accession NZ_LT992476
Organism Staphylococcus aureus isolate 21_LA_436

Toxin (Protein)


Gene name tsbT Uniprot ID X5E2E6
Locus tag DXE57_RS05880 Protein ID WP_000031108.1
Coordinates 1113399..1113551 (+) Length 51 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID W8U4V4
Locus tag DXE57_RS05875 Protein ID WP_001251224.1
Coordinates 1112775..1113374 (+) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DXE57_RS05855 1108691..1110148 + 1458 WP_000649908.1 ABC transporter permease subunit -
DXE57_RS05860 1110141..1110863 + 723 WP_031774878.1 amino acid ABC transporter ATP-binding protein -
DXE57_RS05865 1111014..1112141 + 1128 WP_000379980.1 tRNA epoxyqueuosine(34) reductase QueG -
DXE57_RS05870 1112146..1112616 + 471 WP_000181394.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
DXE57_RS05875 1112775..1113374 + 600 WP_001251224.1 glucosamine-6-phosphate isomerase Antitoxin
DXE57_RS05880 1113399..1113551 + 153 WP_000031108.1 hypothetical protein Toxin
DXE57_RS05890 1114094..1114489 + 396 WP_000901018.1 hypothetical protein -
DXE57_RS05895 1114685..1116070 + 1386 WP_000116238.1 class II fumarate hydratase -
DXE57_RS05900 1116525..1117346 - 822 WP_000669380.1 RluA family pseudouridine synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Glucosamine-6-phosphate isomerase

(124-196)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5936.28 Da        Isoelectric Point: 3.8962

>T294322 WP_000031108.1 NZ_LT992476:1113399-1113551 [Staphylococcus aureus]
MSKDKDPKLNYHEEENSMVTDFEDLKELGKEMEQISDQNDQEKNSEEDSQ

Download         Length: 153 bp

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22343.47 Da        Isoelectric Point: 5.1445

>AT294322 WP_001251224.1 NZ_LT992476:1112775-1113374 [Staphylococcus aureus]
MAMNFKVFDNSQLVAEYAADIIRKQFNNNPTTIAGFHLDTDQAPVLDELKKNVEKHAVDFSQINILDYDDKKSYFEALGV
PAGQVYPIAYEKDAIELIADKIKTKENKGKLTLQVVSIDEQGKLNVSIRQGLMEAREIFLVVTGANKRDVVEKLYQENGK
TSFEPADLKAHRMVNVILDKEAAAGLPEDVKAYFTSRFA

Download         Length: 600 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB X5E2E6

Antitoxin

Source ID Structure
AlphaFold DB W8U4V4

References