Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 951528..952057 Replicon chromosome
Accession NZ_LT992476
Organism Staphylococcus aureus isolate 21_LA_436

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag DXE57_RS04915 Protein ID WP_000621175.1
Coordinates 951695..952057 (+) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID T1YCG8
Locus tag DXE57_RS04910 Protein ID WP_000948331.1
Coordinates 951528..951698 (+) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DXE57_RS04880 946564..947124 + 561 WP_001092419.1 K(+)-transporting ATPase subunit C -
DXE57_RS04885 947333..947812 + 480 WP_001287081.1 hypothetical protein -
DXE57_RS04890 947805..949382 + 1578 WP_001294650.1 PH domain-containing protein -
DXE57_RS04895 949375..949866 + 492 WP_001286980.1 PH domain-containing protein -
DXE57_RS04900 949870..950229 + 360 WP_000581197.1 holo-ACP synthase -
DXE57_RS04905 950295..951443 + 1149 WP_001281139.1 alanine racemase -
DXE57_RS04910 951528..951698 + 171 WP_000948331.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
DXE57_RS04915 951695..952057 + 363 WP_000621175.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
DXE57_RS04925 952407..953408 + 1002 WP_000390829.1 PP2C family protein-serine/threonine phosphatase -
DXE57_RS04930 953527..953853 + 327 WP_001052491.1 anti-sigma factor antagonist -
DXE57_RS04935 953855..954334 + 480 WP_001190825.1 anti-sigma B factor RsbW -
DXE57_RS04940 954309..955079 + 771 WP_001041107.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-110)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13441.69 Da        Isoelectric Point: 10.1654

>T294321 WP_000621175.1 NZ_LT992476:951695-952057 [Staphylococcus aureus]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTYLSDDKMKEVDNALMISLGLNAVAHQKN

Download         Length: 363 bp

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6251.78 Da        Isoelectric Point: 3.8305

>AT294321 WP_000948331.1 NZ_LT992476:951528-951698 [Staphylococcus aureus]
MLSFSQNRSHSLEQSLKEGYSQMADLNLSLANEAFPIECEACDCNETYLSSNSTNE

Download         Length: 171 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VRZ1

References