Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 931806..932320 Replicon chromosome
Accession NZ_LT992476
Organism Staphylococcus aureus isolate 21_LA_436

Toxin (Protein)


Gene name TsdT Uniprot ID T1YA99
Locus tag DXE57_RS04825 Protein ID WP_000581792.1
Coordinates 932111..932320 (+) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID W8UW13
Locus tag DXE57_RS04820 Protein ID WP_000138932.1
Coordinates 931806..932099 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DXE57_RS04800 927569..928884 + 1316 Protein_905 ISL3 family transposase -
DXE57_RS04805 928881..929201 - 321 WP_001825748.1 hypothetical protein -
DXE57_RS04810 929481..930128 - 648 WP_001187614.1 HD domain-containing protein -
DXE57_RS04815 930156..931640 - 1485 WP_000571550.1 cardiolipin synthase -
DXE57_RS04820 931806..932099 + 294 WP_000138932.1 copper-sensing transcriptional repressor CsoR Antitoxin
DXE57_RS04825 932111..932320 + 210 WP_000581792.1 heavy-metal-associated domain-containing protein Toxin
DXE57_RS04830 932448..932585 + 138 WP_000828354.1 hypothetical protein -
DXE57_RS04835 932849..934051 - 1203 WP_001109939.1 rod shape-determining protein RodA -
DXE57_RS04840 934369..935439 + 1071 WP_000159641.1 D-alanine--D-alanine ligase -
DXE57_RS04845 935454..936809 + 1356 WP_000611457.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7843.77 Da        Isoelectric Point: 4.1008

>T294320 WP_000581792.1 NZ_LT992476:932111-932320 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11197.82 Da        Isoelectric Point: 6.2243

>AT294320 WP_000138932.1 NZ_LT992476:931806-932099 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FF1

Antitoxin

Source ID Structure
AlphaFold DB W8UW13

References