Detailed information of TA system TA029432

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafQ(toxin)
• Location: 699709..700282
• Replicon: chromosome
• Accession: NC_021217
• Organism: Helicobacter pylori UM037

Toxin (Protein)

• Gene name: relE
• Uniprot ID: R4Q943
• Locus tag: K750_RS03370
• Protein ID: WP_015644160.1
• Coordinates: 699709..699981 (-)
• Length: 91 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: R4Q6W4
• Locus tag: K750_RS03375
• Protein ID: WP_015644159.1
• Coordinates: 699995..700282 (-)
• Length: 96 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
K750_RS03350	696076..696843	-	768	WP_015644163.1	ABC transporter ATP-binding protein	-
K750_RS03355	696843..697823	-	981	WP_015644162.1	iron ABC transporter permease	-
K750_RS03360	697816..698670	-	855	WP_015644161.1	SDR family oxidoreductase	-
K750_RS03365	698810..699334	+	525	WP_001135603.1	acyl-CoA thioesterase	-
K750_RS03370	699709..699981	-	273	WP_015644160.1	type II toxin-antitoxin system mRNA interferase toxin, HP0892 family	Toxin
K750_RS03375	699995..700282	-	288	WP_015644159.1	type II toxin-antitoxin system antitoxin	Antitoxin
K750_RS03385	701210..703426	-	2217	WP_031942224.1	Hop family adhesin BabA	-
K750_RS08440	704340..704602	-	263	Protein_652	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (1-90)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 91 a.a.
• Molecular weight: 10514.45 Da
• Isoelectric Point: 9.7463

>T29432 WP_015644160.1 NC_021217:c699981-699709 [Helicobacter pylori UM037]
MLTIETSKKFDKDLKILVKNGFDLKLLYKVVGNLATEQPLEPKYKDHPLKGTLKDFRECHLKPDLLLVYQIKKQENTLFL
VRLGSHSELF

Nucleotide

• Length: 273 bp

>T29432 NC_021217:c699981-699709 [Helicobacter pylori UM037]
ATGCTGACGATTGAAACCAGTAAAAAATTTGATAAGGATCTTAAAATTCTTGTTAAAAACGGGTTTGATTTAAAGCTTTT
GTATAAAGTGGTTGGAAATTTAGCCACAGAGCAACCCCTAGAACCCAAATACAAAGACCACCCACTCAAAGGCACTTTAA
AAGATTTTAGGGAGTGCCACCTAAAACCGGATTTATTGCTTGTCTATCAAATTAAAAAACAAGAAAACACTCTTTTTTTA
GTAAGACTGGGCAGTCATAGCGAGTTGTTTTGA

Antitoxin

Protein

• Length: 96 a.a.
• Molecular weight: 11413.19 Da
• Isoelectric Point: 10.4454

>AT29432 WP_015644159.1 NC_021217:c700282-699995 [Helicobacter pylori UM037]
MPNTTNKDYTKYSQRQLFNFLNSIKTKQKRALEKLKEIQTQKQRIKKALQFKALNLTENGYTIEEEREILARAKDTKNRL
CFKSIEDFKKHCENL

Nucleotide

• Length: 288 bp

>AT29432 NC_021217:c700282-699995 [Helicobacter pylori UM037]
ATGCCAAACACCACCAACAAAGATTACACAAAATACAGCCAAAGACAGCTTTTTAATTTTTTAAATTCTATCAAAACCAA
GCAAAAAAGAGCGTTAGAAAAATTGAAAGAAATCCAAACTCAAAAGCAAAGGATTAAAAAAGCGCTCCAATTTAAAGCGC
TAAATCTAACCGAAAATGGATACACCATAGAAGAAGAGCGAGAAATCTTAGCAAGGGCTAAGGACACCAAGAACCGCCTT
TGTTTTAAAAGCATAGAGGATTTTAAAAAACATTGTGAAAACTTATAA

Structures

Toxin

• AlphaFold DB: R4Q943

Antitoxin

• AlphaFold DB: R4Q6W4