Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /HTH_XRE(antitoxin)
Location 2099289..2100086 Replicon chromosome
Accession NZ_LT992475
Organism Staphylococcus aureus isolate 20_LA_415

Toxin (Protein)


Gene name - Uniprot ID -
Locus tag DXE41_RS11235 Protein ID WP_031838007.1
Coordinates 2099625..2100086 (+) Length 154 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID -
Locus tag DXE41_RS11230 Protein ID WP_001260485.1
Coordinates 2099289..2099612 (+) Length 108 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DXE41_RS11180 2095025..2095582 - 558 WP_000645042.1 DUF2815 family protein -
DXE41_RS11185 2095608..2096774 - 1167 WP_000762547.1 DUF2800 domain-containing protein -
DXE41_RS11190 2096771..2097133 - 363 WP_031775157.1 hypothetical protein -
DXE41_RS11195 2097148..2097471 - 324 WP_000174994.1 hypothetical protein -
DXE41_RS11200 2097550..2097711 - 162 WP_001285963.1 DUF1270 family protein -
DXE41_RS11205 2097724..2097987 - 264 WP_001124190.1 helix-turn-helix domain-containing protein -
DXE41_RS11210 2098012..2098227 - 216 WP_001036302.1 hypothetical protein -
DXE41_RS11215 2098282..2098647 + 366 WP_001128433.1 hypothetical protein -
DXE41_RS11220 2098616..2098861 - 246 WP_001025401.1 DUF2829 domain-containing protein -
DXE41_RS11225 2098877..2099125 - 249 WP_000272860.1 helix-turn-helix domain-containing protein -
DXE41_RS11230 2099289..2099612 + 324 WP_001260485.1 helix-turn-helix domain-containing protein Antitoxin
DXE41_RS11235 2099625..2100086 + 462 WP_031838007.1 toxin Toxin
DXE41_RS11240 2100104..2100538 + 435 WP_000755718.1 hypothetical protein -
DXE41_RS11245 2100567..2100962 + 396 WP_000449655.1 hypothetical protein -
DXE41_RS11250 2101052..2101198 + 147 WP_074370993.1 hypothetical protein -
DXE41_RS11255 2101195..2101809 - 615 WP_000191466.1 hypothetical protein -
DXE41_RS11260 2101935..2103140 + 1206 WP_000264745.1 site-specific integrase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2059099..2103140 44041


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(8-65)


Sequences

Toxin        


Download         Length: 154 a.a.        Molecular weight: 18006.39 Da        Isoelectric Point: 4.9167

>T294311 WP_031838007.1 NZ_LT992475:2099625-2100086 [Staphylococcus aureus]
MGLYEETLIQHDYIEIREADVLPDNLDGVWLGDLILIKRGLSDREKAGILFEELAHNKLTYGDIADYSKFNNRKFENYAR
RHGFISAVPLREIVEAHNYGVRNLYELSEYLQLSESYILEAIEQYKKIYGIGTHYGEYSITFEPLRVFKYKEI

Download         Length: 462 bp

Antitoxin


Download         Length: 108 a.a.        Molecular weight: 12439.16 Da        Isoelectric Point: 9.3811

>AT294311 WP_001260485.1 NZ_LT992475:2099289-2099612 [Staphylococcus aureus]
MRTSAEIGKLIKQLRKENNVNLTDFAIKIGVNKSTLSRYENGSRKIPMEDIAEIANALKVTPEYLLLKNRQPENEVQHRA
AHLEGELTDDEWQRVLDYADYIRSKRK

Download         Length: 324 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References